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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Identification of Novel α-Glucosidase Inhibitors by Screening Libraries Based on N- [4-(Benzyloxy) Benzoyl] Alanine Derivatives
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Issue 7, Nov 2002, p. 545 - 550
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- 01 Nov 2002
Abstract
A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for α-glucosidase inhibitory activity. Four compounds showed potent inhibition, six compounds moderate inhibition, and 16 were weak inhibitors. One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of α-glucosidase with 100% inhibition at 1μM. This inhibitor was at least five times more potent than the lead compound I.
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