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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Issue 3, May 2001, p. 287 - 293
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- 01 May 2001
Abstract
An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.
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