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2000
Volume 4, Issue 3
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

A library of 24 glycoconjugates related to glycosylated b-amino acid derivative (I) was been prepared and screened against DNA topoisomerase-II of the filarial parasite S. cervi. Among these, compound 6 was found to be a potent inhibitor of DNA topoisomerase-II with 95percent inhibition at 1.0?mM. Furthermore, compound 6 was at least three times more potent than the lead compound, glycosylated b-amino acid derivative I.

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/content/journals/cchts/10.2174/1386207013331084
2001-05-01
2025-07-08
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