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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Identification of Inhibitors of DNA Topoisomerase II from a Synthetic Library of Glycoconjugates
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Issue 3, May 2001, p. 237 - 234
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- 01 May 2001
Abstract
A library of 24 glycoconjugates related to glycosylated b-amino acid derivative (I) was been prepared and screened against DNA topoisomerase-II of the filarial parasite S. cervi. Among these, compound 6 was found to be a potent inhibitor of DNA topoisomerase-II with 95percent inhibition at 1.0?mM. Furthermore, compound 6 was at least three times more potent than the lead compound, glycosylated b-amino acid derivative I.
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