Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Combinatorial Chemistry & High Throughput Screening
  4. Fast Track Articles
  5. Fast Track Article
image of Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway

Abstract

Cardiovascular diseases (CVDs) remain a key contributor to global morbidity and mortality. Being a vital regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) is a crucial player in CVD treatment. Recently, increasing attention has been paid to the effect of natural drugs on CVDs. According to some studies, HIF-1α is a potential target for CVD treatment in traditional Chinese medicine. In this study, we describe the mechanism underlying the regulatory role of HIF-1α in CVDs and summarize 30 natural drugs and 3 formulations for CVD treatment through HIF-1α and its signaling pathway. The study provides new ideas for CVD prevention and treatment.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cchts/10.2174/0113862073331615241018081811
2024-11-05
2025-03-01

  • From This Site

    /content/journals/cchts/10.2174/0113862073331615241018081811
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Abe H. Semba H. Takeda N. The roles of hypoxia signaling in the pathogenesis of CVD. J. Atheroscler. Thromb. 2017 24 9 884 894 10.5551/jat.RV17009 28757538
    [Google Scholar]
  2. Wu L. Chen Y. Chen Y. Yang W. Han Y. Lu L. Yang K. Cao J. Effect of HIF‐1α/miR‐10b‐5p/PTEN on hypoxia‐induced cardiomyocyte apoptosis. J. Am. Heart Assoc. 2019 8 18 e011948 10.1161/JAHA.119.011948 31480879
    [Google Scholar]
  3. Li X. Zhang Q. Nasser M.I. Xu L. Zhang X. Zhu P. He Q. Zhao M. Oxygen homeostasis and cardiovascular disease: A role for HIF? Biomed. Pharmacother. 2020 128 110338 10.1016/j.biopha.2020.110338 32526454
    [Google Scholar]
  4. Wang G.L. Jiang B.H. Semenza G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 1995 216 2 669 675 10.1006/bbrc.1995.2674 7488163
    [Google Scholar]
  5. Yang S.L. Wu C. Xiong Z.F. Fang X. Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review). Mol. Med. Rep. 2015 12 2 2411 2416 10.3892/mmr.2015.3689 25936862
    [Google Scholar]
  6. Lee Ji-Won Bae S.-H. Jeong J.-W. Kim S.-H. Kim K.-W. Hypoxia-inducible factor (HIF-1)α: Its protein stability and biological functions. Exp. Mol. Med. 36 1 2 2004 10.1038/emm.2004.1
    [Google Scholar]
  7. Xu R. Wang F. Yang H. Wang Z. Action sites and clinical application of hif-1α inhibitors. Molecules 2022 27 11 3426 10.3390/molecules27113426 35684364
    [Google Scholar]
  8. Sheng Z. Lu W. Zuo Z. Wang D. Zuo P. Yao Y. Ma G. MicroRNA‐7b attenuates ischemia/reperfusion‐induced H9C2 cardiomyocyte apoptosis via the hypoxia inducible factor‐1/p‐p38 pathway. J. Cell. Biochem. 2019 120 6 9947 9955 10.1002/jcb.28277 30548297
    [Google Scholar]
  9. Geng B. Wang X. Park K.H. Lee K.E. Kim J. Chen P. Zhou X. Tan T. Yang C. Zou X. Janssen P.M. Cao L. Ye L. Wang X. Cai C. Zhu H. UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway. Redox Biol. 2022 52 102295 10.1016/j.redox.2022.102295 35339825
    [Google Scholar]
  10. Li S. Li S. Effects of transplantation of hypoxia inducible factor-1α gene-modified cardiac stem cells on cardiac function of heart failure rats after myocardial infarction. Anatol. J. Cardiol. 2018 20 6 318 329 10.14744/AnatolJCardiol.2018.91979 30504732
    [Google Scholar]
  11. Zhang Y. Liu D. Hu H. Zhang P. Xie R. Cui W. HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury. Biomed. Pharmacother. 2019 120 109464 10.1016/j.biopha.2019.109464 31590128
    [Google Scholar]
  12. Janbandhu V. Tallapragada V. Patrick R. Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following MI. Cell Stem Cell 2022 29 2 281 297.e12 10.1016/j.stem.2021.10.009 34762860
    [Google Scholar]
  13. Kido M. Du L. Sullivan C.C. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after MI in the mouse. J. Am. Coll. Cardiol. 2005 46 11 2116 2124 10.1016/j.jacc.2005.08.045 16325051
    [Google Scholar]
  14. Chen Q.F. Wang W. Huang Z. Huang D.L. Hypoxia-inducible factor-1α attenuates myocardial inflammatory injury in rats induced by coronary microembolization An. Acad. Bras. Cienc. 92 1 e20190658 2020 10.1590/0001‑3765202020190658 32428089
    [Google Scholar]
  15. Lai X.X. Zhang N. Chen L.Y. Latifolin protects against MI by alleviating myocardial inflammatory via the HIF-1α/NF-κB/IL-6 pathway. Pharm. Biol. 2020 58 1 1156 1166 10.1080/13880209.2020.1840597 33222562
    [Google Scholar]
  16. Guo L. Zhang X. Lv N. Wang L. Gan J. Jiang X. Wang Y. Therapeutic role and potential mechanism of resveratrol in atherosclerosis: TLR4/NF-κB/HIF-1α. Mediators Inflamm. 2023 2023 1 13 10.1155/2023/1097706 37292256
    [Google Scholar]
  17. Waltenberger B. Mocan A. Šmejkal K. Heiss E. Atanasov A. Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules 2016 21 6 807 10.3390/molecules21060807 27338339
    [Google Scholar]
  18. Liu X.W. Lu M.K. Zhong H.T. Wang L.H. Fu Y.P. Panax notoginseng saponins attenuate myocardial ischemia-reperfusion injury through the HIF-1α/BNIP3 pathway of autophagy. J. Cardiovasc. Pharmacol. 2019 73 2 92 99 10.1097/FJC.0000000000000640 30531436
    [Google Scholar]
  19. Liu X.W. Lu M.K. Zhong H.T. Liu J.J. Fu Y.P. Panax notoginseng saponins protect H9c2 cells from hypoxia-reoxygenation injury through the forkhead Box O3a hypoxia-inducible factor-1 alpha cell signaling pathway. J. Cardiovasc. Pharmacol. 2021 78 5 e681 e689 10.1097/FJC.0000000000001120 34354001
    [Google Scholar]
  20. Jiang L. Zeng H. Ni L. Qi L. Xu Y. Xia L. Yu Y. Liu B. Yang H. Hao H. Li P. HIF-1α preconditioning potentiates antioxidant activity in ischemic injury: The role of sequential administration of dihydrotanshinone I and protocatechuic aldehyde in cardioprotection. Antioxid. Redox Signal. 2019 31 3 227 242 10.1089/ars.2018.7624 30799630
    [Google Scholar]
  21. Dong P. Li H. Yu X. Li Q. Liu J. Liu C. Han H. Effect and mechanism of “Danggui–kushen” herb pair on ischemic heart disease. Biomed. Pharmacother. 2022 145 112450 10.1016/j.biopha.2021.112450 34839257
    [Google Scholar]
  22. Todde V. Veenhuis M. van der Klei I.J. Autophagy: Principles and significance in health and disease. Biochim. Biophys. Acta Mol. Basis Dis. 2009 1792 1 3 13 10.1016/j.bbadis.2008.10.016 19022377
    [Google Scholar]
  23. Zhang J. Ney P.A. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ. 2009 16 7 939 946 10.1038/cdd.2009.16 19229244
    [Google Scholar]
  24. Feng C.C. Lin C.C. Lai Y.P. Chen T.S. Marthandam Asokan S. Lin J.Y. Lin K.H. Viswanadha V.P. Kuo W.W. Huang C.Y. Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression. Growth Factors 2016 34 3-4 73 86 10.1080/08977194.2016.1191480 27366871
    [Google Scholar]
  25. Kong L.Y. Xi Z. Ma W.T. Yang F.Y. Niu L.D. Shi J.H. Effects of Notch signal on the expressions of HIF-α and autophagy- related genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation induced myocardial cell injury. Chung Kuo Ying Yung Sheng Li Hsueh Tsa Chih 2019 35 2 165 168 10.12047/j.cjap.5729.2019.036 31250610
    [Google Scholar]
  26. Huang B. Chen N. Chen Z. Shen J. Zhang H. Wang C. Sun Y. HIF‐1α contributes to hypoxia‐induced VSMC proliferation and migration by regulating autophagy in type A aortic dissection. Adv. Biol. 2024 8 1 2300292 10.1002/adbi.202300292 37786269
    [Google Scholar]
  27. van der Pol A. van Gilst W.H. Voors A.A. van der Meer P. Treating oxidative stress in heart failure: Past, present and future. Eur. J. Heart Fail. 2019 21 4 425 435 10.1002/ejhf.1320 30338885
    [Google Scholar]
  28. Jabs T. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem. Pharmacol. 1999 57 3 231 245 10.1016/S0006‑2952(98)00227‑5 9890550
    [Google Scholar]
  29. Poyton R.O. Ball K.A. Castello P.R. Mitochondrial generation of free radicals and hypoxic signaling. Trends Endocrinol. Metab. 2009 20 7 332 340 10.1016/j.tem.2009.04.001 19733481
    [Google Scholar]
  30. Fang J. Seki T. Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv. Drug Deliv. Rev. 2009 61 4 290 302 10.1016/j.addr.2009.02.005 19249331
    [Google Scholar]
  31. Semenza G.L. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis. Curr. Opin. Genet. Dev. 1998 8 5 588 594 10.1016/S0959‑437X(98)80016‑6 9794818
    [Google Scholar]
  32. Li H.S. Zhou Y.N. Li L. Li S.F. Long D. Chen X.L. Zhang J.B. Feng L. Li Y.P. HIF-1α protects against oxidative stress by directly targeting mitochondria. Redox Biol. 2019 25 101109 10.1016/j.redox.2019.101109 30686776
    [Google Scholar]
  33. David B.T. Curtin J.J. Goldberg D.C. Scorpio K. Kandaswamy V. Hill C.E. Hypoxia-inducible factor 1α (HIF-1α) counteracts the acute death of cells transplanted into the injured spinal cord. eNeuro 2020 7 3 ENEURO.0092-19.2019 10.1523/ENEURO.0092‑19.2019 31488552
    [Google Scholar]
  34. David B.T. Curtin J.J. Brown J.L. Coutts D.J.C. Boles N.C. Hill C.E. Treatment with hypoxia‐mimetics protects cultured rat Schwann cells against oxidative stress‐induced cell death. Glia 2021 69 9 2215 2234 10.1002/glia.24019 34019306
    [Google Scholar]
  35. Mitsos S. Katsanos K. Koletsis E. Kagadis G.C. Anastasiou N. Diamantopoulos A. Karnabatidis D. Dougenis D. Therapeutic angiogenesis for myocardial ischemia revisited: Basic biological concepts and focus on latest clinical trials. Angiogenesis 2012 15 1 1 22 10.1007/s10456‑011‑9240‑2 22120824
    [Google Scholar]
  36. Mengozzi M. Cervellini I. Villa P. Erbayraktar Z. Gökmen N. Yilmaz O. Erbayraktar S. Manohasandra M. Van Hummelen P. Vandenabeele P. Chernajovsky Y. Annenkov A. Ghezzi P. Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. Proc. Natl. Acad. Sci. USA 2012 109 24 9617 9622 10.1073/pnas.1200554109 22645329
    [Google Scholar]
  37. Hong M. Shi H. Wang N. Tan H.Y. Wang Q. Feng Y. Dual effects of Chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: Role of HIF-1 network. Front. Pharmacol. 2019 10 696 10.3389/fphar.2019.00696 31297056
    [Google Scholar]
  38. Song W. Liang Q. Cai M. Tian Z. HIF-1α-induced up-regulation of microRNA-126 contributes to the effectiveness of exercise training on myocardial angiogenesis in MI rats. J. Cell. Mol. Med. 2020 24 22 12970 12979 10.1111/jcmm.15892 32939968
    [Google Scholar]
  39. Wen X. Peng Y. Gao M. Endothelial transient receptor potential canonical channel regulates angiogenesis and promotes recovery after MI. J. Am. Heart Assoc. 2022 11 6 e023678 10.1161/JAHA.121.023678 35253458
    [Google Scholar]
  40. Eltzschig H.K. Carmeliet P. Hypoxia and inflammation. N. Engl. J. Med. 2011 364 7 656 665 10.1056/NEJMra0910283 21323543
    [Google Scholar]
  41. Ishii D. Schenk A.D. Baba S. Fairchild R.L. Role of TNFalpha in early chemokine production and leukocyte infiltration into heart allografts. Am. J. Transplant. 2010 10 1 59 68 10.1111/j.1600‑6143.2009.02921.x 19958333
    [Google Scholar]
  42. Chen X. Li X. Zhang W. He J. Xu B. Lei B. Wang Z. Cates C. Rousselle T. Li J. Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway. Metabolism 2018 83 256 270 10.1016/j.metabol.2018.03.004 29526538
    [Google Scholar]
  43. Zhou P. Xie W. Sun Y. Dai Z. Li G. Sun G. Sun X. Ginsenoside Rb1 and mitochondria: A short review of the literature. Mol. Cell. Probes 2019 43 1 5 10.1016/j.mcp.2018.12.001 30529056
    [Google Scholar]
  44. Fan W. Huang Y. Zheng H. Ginsenosides for the treatment of metabolic syndrome and CVD: Pharmacology and mechanisms. Biomed. Pharmacother. 2020 132 110915 10.1016/j.biopha.2020.110915 33254433
    [Google Scholar]
  45. Jiang L. Yin X. Chen Y.H. Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I. Theranostics. 2021;11(4):1703. Published 1720 2021 Jan 1 10.7150/thno.43895 33408776
    [Google Scholar]
  46. Qin L. Fan S. Jia R. Liu Y. Ginsenoside Rg1 protects cardiomyocytes from hypoxia-induced injury through the PI3K/AKT/mTOR pathway. Pharmazie 2018 73 6 349 355 10.1691/ph.2018.8329 29880088
    [Google Scholar]
  47. Yuan C. Wang H. Yuan Z. Ginsenoside Rg1 inhibits myocardial ischaemia and reperfusion injury via HIF-1 α-ERK signalling pathways in a diabetic rat model. Pharmazie 2019 74 3 157 162 10.1691/ph.2019.8858 30961682
    [Google Scholar]
  48. Li J. Yang Y.L. Li L.Z. Zhang L. Liu Q. Liu K. Li P. Liu B. Qi L.W. Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1. Biochim. Biophys. Acta Mol. Basis Dis. 2017 1863 11 2835 2847 10.1016/j.bbadis.2017.07.017 28736181
    [Google Scholar]
  49. Liu J. Wang Y. Qiu L. Yu Y. Wang C. Saponins of Panax notoginseng: Chemistry, cellular targets and therapeutic opportunities in CVD. Expert Opin. Investig. Drugs 2014 23 4 523 539 10.1517/13543784.2014.892582 24555869
    [Google Scholar]
  50. Fan J.S. Liu D.N. Huang G. Xu Z.Z. Jia Y. Zhang H.G. Li X.H. He F.T. Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression. J. Ethnopharmacol. 2012 142 3 732 738 10.1016/j.jep.2012.05.053 22683903
    [Google Scholar]
  51. Zang Y. Wan J. Zhang Z. Huang S. Liu X. Zhang W. An updated role of astragaloside IV in heart failure. Biomed. Pharmacother. 2020 126 110012 10.1016/j.biopha.2020.110012 32213428
    [Google Scholar]
  52. Tan Y.Q. Chen H.W. Li J. Astragaloside I.V. An effective drug for the treatment of CVD. Drug Des. Devel. Ther. 2020 14 3731 3746 10.2147/DDDT.S272355 32982178
    [Google Scholar]
  53. Yu J. Zhang X. Zhang Y. Astragaloside attenuates myocardial injury in a rat model of acute MI by upregulating hypoxia inducible factor-1α and Notch1/Jagged1 signaling. Mol. Med. Rep. 2017 15 6 4015 4020 10.3892/mmr.2017.6522 28487976
    [Google Scholar]
  54. Semwal P. Painuli S. Abu-Izneid T. Rauf A. Sharma A. Daştan S.D. Kumar M. Alshehri M.M. Taheri Y. Das R. Mitra S. Emran T.B. Sharifi-Rad J. Calina D. Cho W.C. Diosgenin: An updated pharmacological review and therapeutic perspectives. Oxid. Med. Cell. Longev. 2022 2022 1 17 10.1155/2022/1035441 35677108
    [Google Scholar]
  55. Zhang S.Q. Song Y.X. Zhang W.X. Chen M.J. Man S.L. Research on anti-tumor natural product diosgenin. Zhongguo Zhongyao Zazhi 2021 46 17 4360 4366 10.19540/j.cnki.cjcmm.20210610.701 34581038
    [Google Scholar]
  56. Li X. Liu S. Qu L. Chen Y. Yuan C. Qin A. Liang J. Huang Q. Jiang M. Zou W. Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases. J. Ethnopharmacol. 2021 274 114018 10.1016/j.jep.2021.114018 33716083
    [Google Scholar]
  57. Li X. Liang J. Qin A. Wang T. Liu S. Li W. Yuan C. Qu L. Zou W. Protective effect of Di’ao Xinxuekang capsule against doxorubicin-induced chronic cardiotoxicity. J. Ethnopharmacol. 2022 287 114943 10.1016/j.jep.2021.114943 34954266
    [Google Scholar]
  58. Sun M.Y. Ma D.S. Zhao S. Wang L. Ma C.Y. Bai Y. Salidroside mitigates hypoxia/reoxygenation injury by alleviating endoplasmic reticulum stress‑induced apoptosis in H9c2 cardiomyocytes. Mol. Med. Rep. 2018 18 4 3760 3768 10.3892/mmr.2018.9403 30132527
    [Google Scholar]
  59. Gao X.F. Shi H.M. Sun T. Ao H. Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute MI. J. Chin. Integr. Med. 2009 7 5 434 440 10.3736/jcim20090507 19435557
    [Google Scholar]
  60. Lv J. Sharma A. Zhang T. Wu Y. Ding X. Pharmacological review on asiatic acid and its derivatives: A potential compound. SLAS Technol. 2018 23 2 111 127 10.1177/2472630317751840 29361877
    [Google Scholar]
  61. Ma Z.G. Dai J. Wei W.Y. Zhang W.B. Xu S.C. Liao H.H. Yang Z. Tang Q.Z. Asiatic acid protects against cardiac hypertrophy through activating AMPKα signalling pathway. Int. J. Biol. Sci. 2016 12 7 861 871 10.7150/ijbs.14213 27313499
    [Google Scholar]
  62. Huo L. Shi W. Chong L. Wang J. Zhang K. Li Y. Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of MI. Exp. Ther. Med. 2016 11 1 57 64 10.3892/etm.2015.2871 26889217
    [Google Scholar]
  63. Huang X. Zuo L. Lv Y. Chen C. Yang Y. Xin H. Li Y. Qian Y. Asiatic acid attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β/HIF-1α signaling in rat H9c2 cardiomyocytes. Molecules 2016 21 9 1248 10.3390/molecules21091248 27657024
    [Google Scholar]
  64. Wu K. Hu M. Chen Z. Xiang F. Chen G. Yan W. Peng Q. Chen X. Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR‐1290. IUBMB Life 2017 69 9 660 667 10.1002/iub.1648 28686797
    [Google Scholar]
  65. Dong Y. Morris-Natschke S.L. Lee K.H. Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Nat. Prod. Rep. 2011 28 3 529 542 10.1039/c0np00035c 21225077
    [Google Scholar]
  66. Wu X. Liu L. Zheng Q. Ye H. Yang H. Hao H. Li P. Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. Acta Pharm. Sin. B 2023 13 1 113 127 10.1016/j.apsb.2022.07.006 36815040
    [Google Scholar]
  67. Li X. Sun C. Zhang J. Protective effects of paeoniflorin on CVD: A pharmacological and mechanistic overview. Front. Pharmacol. 2023 14 1122969 10.3389/fphar.2023.1122969 37324475
    [Google Scholar]
  68. Ji Q. Yang L. Zhou J. Lin R. Zhang J. Lin Q. Wang W. Zhang K. Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway. Toxicol. In Vitro 2012 26 3 455 461 10.1016/j.tiv.2012.01.016 22269387
    [Google Scholar]
  69. Xu D. Li Y. Wang J. Davey A.K. Zhang S. Evans A.M. The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury. Life Sci. 2007 80 4 269 274 10.1016/j.lfs.2006.09.008 17055001
    [Google Scholar]
  70. Liu F. Song L. Lu Z. Isosteviol improves cardiac function and promotes angiogenesis after MI in rats. Cell Tissue Res. 2022 387 2 275 285 10.1007/s00441‑021‑03559‑9 34820705
    [Google Scholar]
  71. Yang Y.H. Mao J.W. Tan X.L. Research progress on the source, production, and anti-cancer mechanisms of paclitaxel. Chin. J. Nat. Med. 2020 18 12 890 897 10.1016/S1875‑5364(20)60032‑2 33357719
    [Google Scholar]
  72. Guo H. Zheng M. Jiao Y.B. Zheng H. Paclitaxel enhances the protective effect of myocardial ischemia preconditioning on ischemia/reperfusion injury in aged rat. Zhonghua Xin Xue Guan Bing Za Zhi 2018 46 9 719 724 10.3760/cma.j.issn.0253‑3758.2018.09.009 30293379
    [Google Scholar]
  73. Thomas S.D. Jha N.K. Jha S.K. Sadek B. Ojha S. Pharmacological and molecular insight on the cardioprotective role of apigenin. Nutrients 2023 15 2 385 10.3390/nu15020385 36678254
    [Google Scholar]
  74. Wang F. Zhang J. Niu G. Weng J. Zhang Q. Xie M. Li C. Sun K. Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions. Drug Dev. Res. 2022 83 4 1003 1015 10.1002/ddr.21928 35277868
    [Google Scholar]
  75. Zhu Z.Y. Gao T. Huang Y. Xue J. Xie M.L. Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats. Food Funct. 2016 7 4 1992 1998 10.1039/C5FO01464F 26987380
    [Google Scholar]
  76. Zhu Z.Y. Wang F. Jia C.H. Xie M.L. Apigenin-induced HIF-1α inhibitory effect improves abnormal glucolipid metabolism in AngⅡ/hypoxia-stimulated or HIF-1α-overexpressed H9c2 cells. Phytomedicine 2019 62 152713 10.1016/j.phymed.2018.10.010 31078968
    [Google Scholar]
  77. Perez-Vizcaino F. Duarte J. Flavonols and cardiovascular disease. Mol. Aspects Med. 2010 31 6 478 494 10.1016/j.mam.2010.09.002 20837053
    [Google Scholar]
  78. Fan R. Sui Y. Study on mechanism of invigorating Qi and promoting blood circulation in treatment of angiogenesis after MI using network pharmacology. Evid. Based Complement. Alternat. Med. 2022 2022 5093486 10.1155/2022/5093486 35656461
    [Google Scholar]
  79. Li W. Li Y. Sun R. Zhou S. Li M. Feng M. Xie Y. Dual character of flavonoids in attenuating and aggravating ischemia-reperfusion-induced myocardial injury. Exp. Ther. Med. 2017 14 2 1307 1314 10.3892/etm.2017.4670 28810591
    [Google Scholar]
  80. Cavia-Saiz M. Busto M.D. Pilar-Izquierdo M.C. Ortega N. Perez-Mateos M. Muñiz P. Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: A comparative study. J. Sci. Food Agric. 2010 90 7 1238 1244 10.1002/jsfa.3959 20394007
    [Google Scholar]
  81. Heidary Moghaddam R. Samimi Z. Moradi S.Z. Little P.J. Xu S. Farzaei M.H. Naringenin and naringin in cardiovascular disease prevention: A preclinical review. Eur. J. Pharmacol. 2020 887 173535 10.1016/j.ejphar.2020.173535 32910944
    [Google Scholar]
  82. Li S. Jiang J. Fang J. Li X. Huang C. Liang W. Wu K. Naringin protects H9C2 cardiomyocytes from chemical hypoxia‑induced injury by promoting the autophagic flux via the activation of the HIF‑1α/BNIP3 signaling pathway. Int. J. Mol. Med. 2021 47 6 102 10.3892/ijmm.2021.4935 33907819
    [Google Scholar]
  83. Zhou Y.X. Zhang H. Peng C. Puerarin: A review of pharmacological effects. Phytother. Res. 2014 28 7 961 975 10.1002/ptr.5083 24339367
    [Google Scholar]
  84. Zhang S. Chen S. Shen Y. Puerarin induces angiogenesis in myocardium of rat with MI. Biol. Pharm. Bull. 2006 29 5 945 950 10.1248/bpb.29.945 16651724
    [Google Scholar]
  85. Xu J. Tian Z. Li Z. Du X. Cui Y. Wang J. Gao M. Hou Y. Puerarin-tanshinone IIA suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis. J. Ethnopharmacol. 2023 317 116675 10.1016/j.jep.2023.116675 37257708
    [Google Scholar]
  86. Lee D.S. Kim K.S. Ko W. Li B. Keo S. Jeong G.S. Oh H. Kim Y.C. The neoflavonoid latifolin isolated from MeOH extract of Dalbergia odorifera attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Phytother. Res. 2014 28 8 1216 1223 10.1002/ptr.5119 24474433
    [Google Scholar]
  87. Yin H.Q. Lee B.W. Kim Y.C. Sohn D.H. Lee B.H. Induction of the anticarcinogenic marker enzyme, quinone reductase, by Dalbergiae Lignum. Arch. Pharm. Res. 2004 27 9 919 922 10.1007/BF02975844 15473661
    [Google Scholar]
  88. Lim S.H. Li B.S. Zhu R.Z. Seo J.H. Choi B.M. Latifolin inhibits oxidative stress-induced senescence via upregulation of SIRT1 in human dermal fibroblasts. Biol. Pharm. Bull. 2020 43 7 1104 1110 10.1248/bpb.b20‑00094 32404543
    [Google Scholar]
  89. Gupta S.C. Patchva S. Aggarwal B.B. Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS J. 2013 15 1 195 218 10.1208/s12248‑012‑9432‑8 23143785
    [Google Scholar]
  90. Pourbagher-Shahri A.M. Farkhondeh T. Ashrafizadeh M. Talebi M. Samargahndian S. Curcumin and CVD: Focus on cellular targets and cascades. Biomed. Pharmacother. 2021 136 111214 10.1016/j.biopha.2020.111214 33450488
    [Google Scholar]
  91. Chen X. Xie Q. Zhu Y. Xu J. Lin G. Liu S. Su Z. Lai X. Li Q. Xie J. Yang X. Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways. Eur. J. Pharmacol. 2021 911 174495 10.1016/j.ejphar.2021.174495 34555398
    [Google Scholar]
  92. Moulin S. Arnaud C. Bouyon S. Pépin J.L. Godin-Ribuot D. Belaidi E. Curcumin prevents chronic intermittent hypoxia-induced myocardial injury. Ther. Adv. Chronic Dis. 2020 11 10.1177/2040622320922104 32637058
    [Google Scholar]
  93. Ganai A.A. Farooqi H. Bioactivity of genistein: A review of in vitro and in vivo studies. Biomed. Pharmacother. 2015 76 30 38 10.1016/j.biopha.2015.10.026 26653547
    [Google Scholar]
  94. Rasheed S. Rehman K. Shahid M. Suhail S. Akash M.S.H. Therapeutic potentials of genistein: New insights and perspectives. J. Food Biochem. 2022 46 9 e14228 10.1111/jfbc.14228 35579327
    [Google Scholar]
  95. Shi Y.N. Zhang X.Q. Hu Z.Y. Zhang C.J. Liao D.F. Huang H.L. Qin L. Genistein protects H9c2 cardiomyocytes against chemical hypoxia-induced injury via inhibition of apoptosis. Pharmacology 2019 103 5-6 282 290 10.1159/000497061 30808828
    [Google Scholar]
  96. Galiniak S. Aebisher D. Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim. Pol. 2019 66 1 13 21 10.18388/abp.2018_2749 30816367
    [Google Scholar]
  97. Breuss J.M. Atanasov A.G. Uhrin P. Resveratrol and its effects on the vascular system. Int. J. Mol. Sci. 2019 20 7 1523 10.3390/ijms20071523 30934670
    [Google Scholar]
  98. Dyck G.J.B. Raj P. Zieroth S. Dyck J.R.B. Ezekowitz J.A. The effects of resveratrol in patients with cardiovascular disease and heart failure: A narrative review. Int. J. Mol. Sci. 2019 20 4 904 10.3390/ijms20040904 30791450
    [Google Scholar]
  99. Bezerra-Filho C.S.M. Barboza J.N. Souza M.T.S. Sabry P. Ismail N.S.M. de Sousa D.P. Therapeutic potential of vanillin and its main metabolites to regulate the inflammatory response and oxidative stress. Mini Rev. Med. Chem. 2019 19 20 1681 1693 10.2174/1389557519666190312164355 30864521
    [Google Scholar]
  100. Sirangelo I. Sapio L. Ragone A. Naviglio S. Iannuzzi C. Barone D. Giordano A. Borriello M. Vanillin prevents doxorubicin-induced apoptosis and oxidative stress in rat H9c2 cardiomyocytes. Nutrients 2020 12 8 2317 10.3390/nu12082317 32752227
    [Google Scholar]
  101. Elseweidy M.M. Ali S.I. Shaheen M.A. Abdelghafour A.M. Hammad S.K. Vanillin and pentoxifylline ameliorate isoproterenol-induced myocardial injury in rats via the Akt/HIF-1α/VEGF signaling pathway. Food Funct. 2023 14 7 3067 3082 10.1039/D2FO03570G 36917190
    [Google Scholar]
  102. Wang X. Wang D. Deng B. Yan L. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int. Immunopharmacol. 2023 118 109982 10.1016/j.intimp.2023.109982 36989902
    [Google Scholar]
  103. Cho S. Cho M. Kim J. Kaeberlein M. Lee S.J. Suh Y. Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. Oncotarget 2015 6 1 43 55 10.18632/oncotarget.2723 25415049
    [Google Scholar]
  104. Wang K. Feng X. Chai L. Cao S. Qiu F. The metabolism of berberine and its contribution to the pharmacological effects. Drug Metab. Rev. 2017 49 2 139 157 10.1080/03602532.2017.1306544 28290706
    [Google Scholar]
  105. Song D. Hao J. Fan D. Biological properties and clinical applications of berberine. Front. Med. 2020 14 5 564 582 10.1007/s11684‑019‑0724‑6 32335802
    [Google Scholar]
  106. Liu D.Q. Chen S.P. Sun J. Wang X.M. Chen N. Zhou Y.Q. Tian Y.K. Ye D.W. Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies. Pharmacol. Res. 2019 148 104385 10.1016/j.phrs.2019.104385 31400402
    [Google Scholar]
  107. Zhu N. Li J. Li Y. Zhang Y. Du Q. Hao P. Li J. Cao X. Li L. Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis in vitro and myocardial ischemia/reperfusion-induced apoptosis in vivo by regulating the mitophagy-mediated HIF-1α/BNIP3 pathway. Front. Pharmacol. 2020 11 367 10.3389/fphar.2020.00367 32292345
    [Google Scholar]
  108. Haq I.U. Imran M. Nadeem M. Tufail T. Gondal T.A. Mubarak M.S. Piperine: A review of its biological effects. Phytother. Res. 2021 35 2 680 700 10.1002/ptr.6855 32929825
    [Google Scholar]
  109. Taqvi S.I.H. Shah A.J. Gilani A.H. Blood pressure lowering and vasomodulator effects of piperine. J. Cardiovasc. Pharmacol. 2008 52 5 452 458 10.1097/FJC.0b013e31818d07c0 19033825
    [Google Scholar]
  110. Viswanadha V.P. Dhivya V. Beeraka N.M. Huang C.Y. Gavryushova L.V. Minyaeva N.N. Chubarev V.N. Mikhaleva L.M. Tarasov V.V. Aliev G. The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity. Eur. J. Pharmacol. 2020 885 173524 10.1016/j.ejphar.2020.173524 32882215
    [Google Scholar]
  111. Wu L. Ling H. Li L. Jiang L. He M. Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following MI. J. Pharm. Pharmacol. 2007 59 5 695 701 10.1211/jpp.59.5.0010 17524235
    [Google Scholar]
  112. Han Y. Zhang W. Tang Y. Bai W. Yang F. Xie L. Li X. Zhou S. Pan S. Chen Q. Ferro A. Ji Y. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS One 2012 7 6 e38627 10.1371/journal.pone.0038627 22715398
    [Google Scholar]
  113. Shang A. Cao S.Y. Xu X.Y. Gan R.Y. Tang G.Y. Corke H. Mavumengwana V. Li H.B. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods 2019 8 7 246 10.3390/foods8070246 31284512
    [Google Scholar]
  114. Mondal A. Banerjee S. Bose S. Mazumder S. Haber R.A. Farzaei M.H. Bishayee A. Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations. Pharmacol. Res. 2022 175 105837 10.1016/j.phrs.2021.105837 34450316
    [Google Scholar]
  115. Yu L. Di W. Dong X. Li Z. Xue X. Zhang J. Wang Q. Xiao X. Han J. Yang Y. Wang H. Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation. Oncotarget 2017 8 43 74791 74805 10.18632/oncotarget.20422 29088824
    [Google Scholar]
  116. Lin K.H. Wei Y.M. Liu C.H. Liu J.S. Huang I.C. Viswanadha V.P. Huang C.Y. Kuo W.W. Diallyl trisulfide suppresses high-glucose-induced cardiomyocyte apoptosis by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α/insulin-like growth factor binding protein 3 activation. J. Agric. Food Chem. 2021 69 39 11696 11708 10.1021/acs.jafc.1c02384 34558885
    [Google Scholar]
  117. Akbari G. ali Mard S. Veisi A. A comprehensive review on regulatory effects of crocin on ischemia/reperfusion injury in multiple organs. Biomed. Pharmacother. 2018 99 664 670 10.1016/j.biopha.2018.01.113 29710463
    [Google Scholar]
  118. Makaritsis K.P. Kotidis C. Papacharalampous K. Kouvaras E. Poulakida E. Tarantilis P. Asprodini E. Ntaios G. Koukoulis G.Κ. Dalekos G.Ν. Ioannou M. Mechanistic insights on the effect of crocin, an active ingredient of saffron, on atherosclerosis in apolipoprotein E knockout mice. Coron. Artery Dis. 2022 33 5 394 402 10.1097/MCA.0000000000001142 35880561
    [Google Scholar]
  119. Wang F. Li C. Zheng Y. Li Y. Peng G. Study on the anaphylactoid of three phenolic acids in Honeysuckle. J. Ethnopharmacol. 2015 170 1 7 10.1016/j.jep.2015.05.011 25978951
    [Google Scholar]
  120. Hu H. Wu L. Li M. Xue C. Wang G. Chen S. Huang Y. Zheng L. Wang A. Li Y. Gong Z. Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats. Biomed. Chromatogr. 2020 34 1 e4714 10.1002/bmc.4714 31633806
    [Google Scholar]
  121. Li J. Chen X. Li X. Tang J. Li Y. Liu B. Guo S. Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway. Food Funct. 2022 13 4 2269 2282 10.1039/D1FO03838A 35141734
    [Google Scholar]
  122. Chang M.X. Xiong F. Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: Recent advances and future directions. Molecules 2020 25 22 5342 10.3390/molecules25225342 33207669
    [Google Scholar]
  123. Kishimoto Y. Yoshida H. Kondo K. Potential anti-atherosclerotic properties of astaxanthin. Mar. Drugs 2016 14 2 35 10.3390/md14020035 26861359
    [Google Scholar]
  124. Gai Y.S. Ren Y.H. Gao Y. Liu H.N. Astaxanthin protecting myocardial cells from hypoxia/reoxygenation injury by regulating miR-138/HIF-1α axis. Eur. Rev. Med. Pharmacol. Sci. 2020 24 14 7722 7731 10.26355/eurrev_202007_22276 32744699
    [Google Scholar]
  125. Matkowski A. Zielińska S. Oszmiański J. Lamer-Zarawska E. Antioxidant activity of extracts from leaves and roots of Salvia miltiorrhiza Bunge, S. przewalskii Maxim., and S. verticillata L. Bioresour. Technol. 2008 99 16 7892 7896 10.1016/j.biortech.2008.02.013 18396038
    [Google Scholar]
  126. Wang Y. Duo D. Yan Y. He R. Wang S. Wang A. Wu X. Extract of Salvia przewalskii repair tissue damage in chronic hypoxia maybe through the RhoA-ROCK signalling pathway Biol. Pharm. Bull. 2020 43 3 432 439 10.1248/bpb.b19‑00775 31875579
    [Google Scholar]
  127. Miller A.L. Botanical influences on cardiovascular disease. Altern. Med. Rev. 1998 3 6 422 431 9855567
    [Google Scholar]
  128. Swaminathan J.K. Khan M. Mohan I.K. Selvendiran K. Niranjali Devaraj S. Rivera B.K. Kuppusamy P. Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury. Phytomedicine 2010 17 10 744 752 10.1016/j.phymed.2010.01.009 20171068
    [Google Scholar]
  129. Jayachandran K.S. Khan M. Selvendiran K. Devaraj S.N. Kuppusamy P. Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathways. J. Cardiovasc. Pharmacol. 2010 56 5 526 531 10.1097/FJC.0b013e3181f64c51 20729753
    [Google Scholar]
  130. Liu T. Yan T. Jia X. Systematic exploration of the potential material basis and molecular mechanism of the Mongolian medicine Nutmeg-5 in improving cardiac remodeling after MI. J. Ethnopharmacol. 2022 285 114847 10.1016/j.jep.2021.114847 34800647
    [Google Scholar]
  131. Lin S.S. Liu C.X. Wang X.L. Mao J.Y. Intervention mechanisms of xinmailong injection, a Periplaneta americana extract, on cardiovascular disease: A systematic review of basic researches. Evid. Based Complement. Alternat. Med. 2019 2019 1 13 10.1155/2019/8512405 32454845
    [Google Scholar]
  132. Zhang W. Li K. Ding Y. Ren J. Wang H. Si Q. Protective effect of xinmailong injection on rats with MI. Front. Physiol. 2021 11 595760 10.3389/fphys.2020.595760 33584329
    [Google Scholar]
  133. Huang L.X. Wu X.H. Effect of Xinmailong on hypoxia-inducible factor-1alpha expression in neonatal rats with asphyxia. Zhongguo Dang Dai Er Ke Za Zhi 2009 11 8 683 686 19695202
    [Google Scholar]
  134. Semenza G.L. The genomics and genetics of oxygen homeostasis. Annu. Rev. Genomics Hum. Genet. 2020 21 1 183 204 10.1146/annurev‑genom‑111119‑073356 32255719
    [Google Scholar]
  135. Hsu T.S. Lin Y.L. Wang Y.A. Mo S.T. Chi P.Y. Lai A.C.Y. Pan H.Y. Chang Y.J. Lai M.Z. HIF-2α is indispensable for regulatory T cell function. Nat. Commun. 2020 11 1 5005 10.1038/s41467‑020‑18731‑y 33024109
    [Google Scholar]
  136. Han H. Saeidi S. Kim S.J. Piao J.Y. Lim S. Guillen-Quispe Y.N. Choi B.Y. Surh Y.J. Alternative regulation of HIF-1α stability through Phosphorylation on Ser451. Biochem. Biophys. Res. Commun. 2021 545 150 156 10.1016/j.bbrc.2021.01.047 33550096
    [Google Scholar]
  137. Lendahl U. Lee K.L. Yang H. Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat. Rev. Genet. 2009 10 12 821 832 10.1038/nrg2665 19884889
    [Google Scholar]
/content/journals/cchts/10.2174/0113862073331615241018081811
Loading
Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway
Bentham Science Publishers ; https://doi.org/10.2174/0113862073331615241018081811
/content/journals/cchts/10.2174/0113862073331615241018081811
/content/journals/cchts/10.2174/0113862073331615241018081811
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: autophagy ; oxidative stress ; angiogenesis ; natural drugs ; HIF-1α ; Cardiovascular disease ; inflammation ; flavonoids

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test