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image of Regulation of Curcumin on Follicle Initiation Rate in Diminished Ovarian Reserve

Abstract

Aim

To study the mechanism by which curcumin regulates ovarian primordial follicle initiation in rats with triptolide-induced diminished ovarian reserve (DOR).

Methods

An in vitro gelatin sponge culture was performed on 3-day-old rat ovaries. After the establishment of the DOR model with triptolide, curcumin was administered for 3 days. Histological analysis and follicle counts were performed using H&E staining. ELISA detection of ovarian hormones in the culture medium (E, FSH and LH), western blotting and Q-PCR for protein and mRNA expression (LTCONS-00011173, TGF-β1, Smad1, AMH, PTEN and GDF-9).

Results

Ovarian primordial and growing follicles increased significantly after curcumin intervention ( < 0.05), FSH/LH and E levels were increased significantly ( < 0.05). Curcumin also significantly decreased the expression of LTCONS-00011173. Meanwhile, curcumin increased the expression of TGF-β, AMH, and GDF-9 ( < 0.05). In addition, curcumin increased Smad1 gene expression and protein phosphorylation in the ovary on the one hand ( < 0.05), but inhibited Smad1 and p-Smad1 protein expression on the other hand ( < 0.05). Moreover, curcumin decreased PTEN protein and mRNA expression ( < 0.05).

Conclusion

Curcumin activates primordial follicles in DOR model rats through TGF-β1 and downstream AMH signaling pathways and may limit follicle exhaustion through LncRNA.

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2024-11-22

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/content/journals/cchts/10.2174/0113862073327087240926065629
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Regulation of Curcumin on Follicle Initiation Rate in Diminished Ovarian Reserve
Bentham Science Publishers ; https://doi.org/10.2174/0113862073327087240926065629
/content/journals/cchts/10.2174/0113862073327087240926065629
/content/journals/cchts/10.2174/0113862073327087240926065629
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  • Article Type:     Research Article
Keywords: Smad1 ; long non-coding RNA ; Curcumin ; primitive follicle initiation ; transforming growth factor-β

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