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image of The Mechanisms and Quality Markers of Anti-rheumatoid Arthritis of Traditional Chinese Medicine

Abstract

Background

RA is a recurrent autoimmune disease that has significant adverse effects on the physical and mental health of patients. Traditional Chinese medicine has shown significant advantages in the prevention and treatment of RA. Numerous clinical and experimental studies have confirmed that traditional Chinese medicine components have clear therapeutic effects and minimal adverse reactions in treating RA. The research on traditional Chinese medicine for the prevention and treatment of RA has become a hot topic in the field of autoimmune diseases.

Methods

The related references about the mechanisms and Q-markers of anti-RA of traditional Chinese medicine in this review were collected from Willy, SpringLink, Web of Science, Elsevier, PubMed, SciFinder, Scopus, ACS publications, Baidu Scholar, Google Scholar, and CNKI.

Results

The traditional Chinese medicine components such as terpenoids, flavonoids, and alkaloids have significant anti-RA effects, and their mechanisms are mainly to inhibit NF-κB signaling pathway, inhibit the proliferation of RA fibroblasts like synovial cells, and regulate Th1/Th2 cell balance, and so on. Predicting and studying the Q-markers of traditional Chinese medicine anti-RA by plant phylogeny and chemical componentss, traditional medicinal properties, pharmacokinetics, component measurability, correlation between composition and efficacy, and gut microbiota will provide scientific foundations for the research and further development of anti-RA traditional Chinese medicine.

Conclusions

The active components of traditional Chinese medicine exhibited the characteristic of multiple mechanisms in the treatment of RA, such as terpenoids had anti-angiogenesis effects, flavonoids had anti-inflammatory and cartilage protective effects, and alkaloids had anti-inflammatory and analgesic effects. The proposal of Q-markers for anti-RA provided new research ideas for promoting the development of new drugs for anti-RA and ensuring the safety and effectiveness of clinical medications.

© 2024 Bentham Science Publishers
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2024-10-02
2024-11-26

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References

  1. Hu C.L. Lin B. Zheng C.J. Qin L.P. Han T. Advances in studies on natural medicines and their action mechanism for treatment of rheumatoid arthritis. Chin. Tradit. Herbal Drugs 2011 42 1435 1440
    [Google Scholar]
  2. Liu T. Zhang D.S. Research progress on traditional Chinese medicines and their mechanism of anti-rheumatoid arthritis. J. Pharm. Res. 2020 39 44 48
    [Google Scholar]
  3. Qian J.L. Li Z.Y. Research progress on refractory rheumatoid arthritis. Chin. Foreign Med. Res 2024 22 176 179
    [Google Scholar]
  4. Huang J. Fu X. Chen X. Li Z. Huang Y. Liang C. Promising therapeutic targets for treatment of rheumatoid arthritis. Front. Immunol. 2021 12 686155 10.3389/fimmu.2021.686155 34305919
    [Google Scholar]
  5. Ding Q. Hu W. Wang R. Yang Q. Zhu M. Li M. Cai J. Rose P. Mao J. Zhu Y.Z. Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct. Target. Ther. 2023 8 1 68 10.1038/s41392‑023‑01331‑9 36797236
    [Google Scholar]
  6. Gong X. Ma X.L. Jiang Q. Review of clinical research on traditional Chinese medicine treatment of rheumatoid arthritis. J. Basic Clin. Med. 2024 30 953 958
    [Google Scholar]
  7. Zhang J.H. Fan G.W. Zhang H. Fan X.H. Wang Y. Liu L.M. Li C. Gao Y. Gao X.M. The development and application of traditional Chinese medicine component theory. Zhongguo Zhongyao Zazhi 2017 42 4054 4058 29271139
    [Google Scholar]
  8. Tu Y. Li L. Wang Z. Yang L. Advances in analytical techniques and quality control of traditional Chinese medicine injections. J. Pharm. Biomed. Anal. 2021 206 114353 10.1016/j.jpba.2021.114353 34562802
    [Google Scholar]
  9. Meng X.Y. Jiang L.J. Qiu Q. Ye M.F. Liu Y.Y. Zhen D.D. Research advances on quality markers of Chinese materia medica for prevention and treatment of rheumatoid arthritis. Zhonghua Zhongyiyao Xuekan 2022 40 48 53
    [Google Scholar]
  10. Wang Q.Y. He N.X. Qiu Y.W. Jiang W. Zhong G.Y. Sang Z.P. Ma Q.G. Wei R.R. Vicatia thibetica de Boiss: botany, traditional uses, phytochemistry, quantitative analysis, and pharmacology. Comb. Chem. High T. Scr 2024 27 5 679 687 37259928
    [Google Scholar]
  11. Wu G. Guan Y. Chen J. Zhu M.N. Qiu Y.W. Zhu C.Q. Wu Y.Z. Zhong G.Y. Ma Q.G. Wei R.R. Ethnopharmacology, phytochemistry, and pharmacology of Pyrethrum tatsienense (Bureau & Franch.) Ling ex C. Shih: A comprehensive review. Comb. Chem. High T. Scr 2023 26 10 1822 1835 36366841
    [Google Scholar]
  12. Ma Q.G. Wang L. Liu R.H. Yuan J.B. Xiao H. Shen Z.Y. Li J.X. Guo J.Z. Cao L. Huang H.L. Wei R.R. Phyllanthus emblica Linn: A comprehensive review of botany, traditional uses, phytonutrients, health benefits, quality markers, and applications. Food Chem. 2024 446 138891 10.1016/j.foodchem.2024.138891 38432135
    [Google Scholar]
  13. Ma Q.G. He N.X. Huang H.L. Fu X.M. Zhang Z.L. Shu J.C. Wang Q.Y. Chen J. Wu G. Zhu M.N. Sang Z.P. Cao L. Wei R.R. Hippophae rhamnoides L.: A comprehensive review on the botany, traditional uses, phytonutrients, health benefits, quality markers, and applications. J. Agric. Food Chem. 2023 71 12 4769 4788 10.1021/acs.jafc.2c06916 36930583
    [Google Scholar]
  14. Deng L.F. Han Y.Q. Wang Y.Z. Xia L.Z. Research progress on the treatment of rheumatoid arthritis with active ingredients of traditional Chinese medicine. Clin. J. Tradit. Chin. Med 2014 26 761 762
    [Google Scholar]
  15. Wang L. Lan X.Y. Ji J. Zhang C.F. Li F. Wang C.Z. Yuan C.S. Anti-inflammatory and anti-angiogenic activities in vitro of eight diterpenes from Daphne genkwa based on hierarchical cluster and principal component analysis. J. Nat. Med. 2018 72 3 675 685 10.1007/s11418‑018‑1202‑1 29680963
    [Google Scholar]
  16. Li Q. Chen X. Xu Y. Zhang Q. Zhang X. Zhang H. Research on secoiridoid glucoside extracted from Gentiana macrophylla Pall. against collagen induced arthritis based on multivariate statistical analysis. Pharm. Clin. Chin. Mater. Med 2019 35 46 52
    [Google Scholar]
  17. Yang Y. Ye Y. Qiu Q. Xiao Y. Huang M. Shi M. Liang L. Yang X. Xu H. Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway. Int. Immunopharmacol. 2016 41 8 16 10.1016/j.intimp.2016.10.005 27816728
    [Google Scholar]
  18. Feng M.J. Li L. Wang Y.H. Xu J.H. Pan Z. Effects of astragaloside IV on proliferation and interleukin-6 secretion of human rheumatoid arthritis fibroblast like synoviocytes. Chin. J. Basic Med. Tradit. Chin. Med 2020 26 1484 1487
    [Google Scholar]
  19. Ding Y. Zhao Q. Wang L. Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chem. Biol. Interact. 2019 306 131 137 10.1016/j.cbi.2019.04.025 31004595
    [Google Scholar]
  20. Xiong Y. Ma Y. Kodithuwakku N.D. Fang W. Liu L. Li F. Hu Y. Li Y. Protective effects of Clematichinenoside AR against inflammation and cytotoxicity induced by human tumor necrosis factor-α. Int. Immunopharmacol. 2019 75 105563 10.1016/j.intimp.2019.04.010 31408840
    [Google Scholar]
  21. Wang Y. Dai L. Wu H. Zhang Z. Wang W. Fu J. Deng R. Li F. Dai X. Zhan X. Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts. Int. Immunopharmacol. 2018 65 284 294 10.1016/j.intimp.2018.09.049 30342345
    [Google Scholar]
  22. Zhang L. Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol. Ther. 2020 207 107452 10.1016/j.pharmthera.2019.107452 31836457
    [Google Scholar]
  23. Jiang S.H. Ping L.F. Sun F.Y. Wang X.L. Sun Z.J. Protective effect of taraxasterol against rheumatoid arthritis by the modulation of inflammatory responses in mice. Exp. Ther. Med. 2016 12 6 4035 4040 10.3892/etm.2016.3860 28101182
    [Google Scholar]
  24. Jin G.J. Ye Q. Xu Z.L. The analgsic effect and possible mechanisms of geniposide on type II collagen-induced arthritis in rats. Chin. J. New Drug 2018 27 356 360
    [Google Scholar]
  25. Castejón M.L. Rosillo M.Á. Montoya T. González-Benjumea A. Fernández-Bolaños J.M. Alarcón-de-la-Lastra C. Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982. Food Funct. 2017 8 5 1890 1898 10.1039/C7FO00210F 28426090
    [Google Scholar]
  26. Zhang L. Yu J. Wang C. Wei W. The effects of total glucosides of paeony (TGP) and paeoniflorin (Pae) on inflammatory-immune responses in rheumatoid arthritis (RA). Funct. Plant Biol. 2019 46 2 107 117 10.1071/FP18080 32172753
    [Google Scholar]
  27. Mota C.M.D. Rodrigues-Santos C. Carolino R.O.G. Anselmo-Franci J.A. Branco L.G.S. Citral-induced analgesia is associated with increased spinal serotonin, reduced spinal nociceptive signaling, and reduced systemic oxidative stress in arthritis. J. Ethnopharmacol. 2020 250 112486 10.1016/j.jep.2019.112486 31846747
    [Google Scholar]
  28. Tong Z. Cheng L. Song J. Wang M. Yuan J. Li X. Gao H. Wu Z. Therapeutic effects of Caesalpinia minax Hance on complete Freund’s adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components. J. Ethnopharmacol. 2018 226 90 96 10.1016/j.jep.2018.08.011 30114517
    [Google Scholar]
  29. Ma J.F. Meng Q.L. Zheng Z.F. Gu H.M. Hou X.J. Zhu Y.L. Effects of triptolide on IFN-γ and IL-17A expression in collagen-induced arthritic rats. J. Beijing Univ. Tradit. Chin. Med 2020 43 592 598
    [Google Scholar]
  30. Yu Y. Shi L. Yu B. Bian Y. The effects of geniposide on Th17/Treg balance and local inflammatory factors in rats with rheumatoid arthritis. J. Nanjing Univ. Tradit. Chin. Med 2018 34 499 503
    [Google Scholar]
  31. Wang Z. Zhuo F. Chu P. Yang X. Zhao G. Germacrone alleviates collagen-induced arthritis via regulating Th1/Th2 balance and NF-κB activation. Biochem. Biophys. Res. Commun. 2019 518 3 560 564 10.1016/j.bbrc.2019.08.084 31451221
    [Google Scholar]
  32. Zhao S.Y. Bi X.Y. Yang B.Y. Kuang H.X. Wang Q.H. Lv S.W. Analysis of active components of Caulopyhllum robustum against rheumatoid arthritis based on HDAC3/8 molecular interaction technology. Chin. Tradit. Herbal Drugs 2020 51 2117 2124
    [Google Scholar]
  33. Yan X.T. Chen H.G. Zhou X. Research progress of rheumatoid arthritis effect and mechanism of flavonoids. Nat. Prod. Res. Dev 2019 31 1101 1108
    [Google Scholar]
  34. Sun C. Wei J. Bi L. Rutin attenuates oxidative stress and proin-flammatory cytokine level in adjuvant induced rheumatoid arthritis via inhibition of NF-κB. Pharmacology 2017 100 1-2 40 49 10.1159/000451027 28467992
    [Google Scholar]
  35. Wang Y.Q. Chen S.F. Mei J. Quercetin attenuates chondrocytes matrix degradation and apoptosis in rheumatoid arthritis rats by inhibiting NF-κB. Immunol. J. 2019 35 485 491
    [Google Scholar]
  36. Sun Y. Bao Y. Yu H. Chen Q. Lu F. Zhai S. Zhang C. Li F. Wang C. Yuan C. Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa. Int. Immunopharmacol. 2020 83 106384 10.1016/j.intimp.2020.106384 32199350
    [Google Scholar]
  37. Liu X.Y. Xu L. Wang Y. Li J.X. Zhang Y. Zhang C. Wang S.S. Zhang X.M. Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-κB pathway. Int. Immunopharmacol. 2017 44 105 114 10.1016/j.intimp.2017.01.010 28092862
    [Google Scholar]
  38. Zhao L. Cai C. Wang J. Zhao L. Li W. Liu C. Guan H. Zhu Y. Xiao J. Dihydromyricetin protects against bone loss in ovariectomized mice by suppressing osteoclast activity. Front. Pharmacol. 2017 8 928 10.3389/fphar.2017.00928 29311931
    [Google Scholar]
  39. Bai L. Yang Y.X. Wan Q.F. Huang L. Duan H.Z. Baicalin alleviated rheumatoid arthritis synovitis of SD rats through TLR2-NF-κB pathway. Chin. Pharmacol. Bull 2017 33 1569 1573
    [Google Scholar]
  40. Wang Y. Gao J. Xing L.Z. Therapeutic potential of Oroxylin A in rheumatoid arthritis. Int. Immunopharmacol. 2016 40 294 299 10.1016/j.intimp.2016.09.006 27643663
    [Google Scholar]
  41. Li M. Huang S.F. Wu Z.A. Luo Q. He M. Xu N. In vitro study on the effects of baicalin on fibroblast like synovial cells and interleukin-6 expression in rheumatoid arthritis. Hebei J. TCM 2018 40 746 749
    [Google Scholar]
  42. Sun Y. Li L. Cyanidin‐3‐glucoside inhibits inflammatory activities in human fibroblast‐like synoviocytes and in mice with collagen‐induced arthritis. Clin. Exp. Pharmacol. Physiol. 2018 45 10 1038 1045 10.1111/1440‑1681.12970 29779214
    [Google Scholar]
  43. Li Y. Yang B. Bai J. Xia S. Mao M. Li X. Li N. Chen L. The roles of synovial hyperplasia, angiogenesis and osteoclastogenesis in the protective effect of apigenin on collagen-induced arthritis. Int. Immunopharmacol. 2019 73 362 369 10.1016/j.intimp.2019.05.024 31132731
    [Google Scholar]
  44. Kim H.R. Kim B.M. Won J.Y. Lee K.A. Ko H.M. Kang Y.S. Lee S.H. Kim K.W. Quercetin, a plant polyphenol, has potential for the prevention of bone destruction in rheumatoid arthritis. J. Med. Food 2019 22 2 152 161 10.1089/jmf.2018.4259 30596535
    [Google Scholar]
  45. Xiang L. Tong Y.J. Tian X.L. Fang R. Wang F. The effects of icariin on apoptosis of fibroblast-like synovicocytes and expression of cytokines in rheumatoid arthritis. Current Immunology 2020 40 360 365
    [Google Scholar]
  46. Duan H.Z. Bai L. Bai Y. Gao X.S. Wan Q.F. Zhang W. Molecular mechanism of baicalin in reducing HFLS-RA synthesis of extracellular matrix. Lishizhen Med. Mater. Med. Res. 2019 30 1299 1302
    [Google Scholar]
  47. Miao C.G. Qin M.S. Chen J.Z. Li C.F. Zhang B. Li X.F. Li J. Effects of soybean isoflavone on the fibroblast like synoviocytes apoptosis in rheumatoid arthritis model rat. J. Chin. Cereals Oils Assoc 2016 31 1 4
    [Google Scholar]
  48. Pan D. Li N. Liu Y. Xu Q. Liu Q. You Y. Wei Z. Jiang Y. Liu M. Guo T. Cai X. Liu X. Wang Q. Liu M. Lei X. Zhang M. Zhao X. Lin C. Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway. Int. Immunopharmacol. 2018 55 174 182 10.1016/j.intimp.2017.12.011 29268189
    [Google Scholar]
  49. Gou K.J. Zeng R. Ren X.D. Dou Q.L. Yang Q.B. Dong Y. Qu Y. Anti-rheumatoid arthritis effects in adjuvant-induced arthritis in rats and molecular docking studies of Polygonum orientale L. extracts. Immunol. Lett. 2018 201 59 69 10.1016/j.imlet.2018.11.009 30471320
    [Google Scholar]
  50. Mo H.S. Zhou Y.S. Huang Y.D. Yang Q. The therapeutic effect and mechanism of total flavonoids from Phanera championii on adjuvant arthritis rats. Zhongchengyao 2017 39 593 596
    [Google Scholar]
  51. Sun L.J. Wang Y.Y. Fan Z.W. Gu H. Chen X. Zhang C.Y. The effect of Prunus tomentosa Thumb total flavonoids on the inflammation and autophagy of LPS - stimulated rat synovial cells RSC-364. Immunol. J. 2020 36 1059 1064
    [Google Scholar]
  52. Yang Y.X. Kong G.M. Zhu Q. Bu P. Experimental study on the combination of melittin and Eucommia ulmoides flavonoids for topical treatment of rheumatoid arthritis. Lishizhen Med. Mater. Med. Res 2016 27 1833 1836
    [Google Scholar]
  53. Liu B.W. Liu F.L. Wang R.Y. Xue J.W. Liu W.Y. Feng F. Qu W. Chemical constituents of total alkaloids from Picrasma quassioides and its effects on collagen induced arthritis in rats. Zhongguo Yaoke Daxue Xuebao 2019 50 585 592
    [Google Scholar]
  54. Yang X.M. Chen X.L. Zhang Y.P. Yang F.F. Xie L. Yang J.H. Luo C.Y. Zha H. Comparison of improvement effects and its mechanism of different doses of total alkaloids from Aconitum racemulosum on CIA model rats based on information entropy theory. China Pharm 2019 30 2206 2209
    [Google Scholar]
  55. Lu Y. Zhu Y.Z. Guo C.X. Han C. Qian Y.X. Zhu G.F. Pan Y.Y. Anti-inflammatory and analgesic activities of ethanol extract of Toddalia asiatica. Zhongchengyao 2018 40 26 32
    [Google Scholar]
  56. Liu L. Yan J. Shu J.C. Liu J.Q. Advance on alkaloids from Tripterygium wilfordii and their bioactivities. Nat. Prod. Res. Dev 2019 31 2170 2181
    [Google Scholar]
  57. Wu P. Liang Q. Feng P. Li C. Yang C. Liang H. Tang H. Shuai C. A novel brucine gel transdermal delivery system designed for anti-inflammatory and analgesic activities. Int. J. Mol. Sci. 2017 18 4 757 10.3390/ijms18040757 28368343
    [Google Scholar]
  58. He Y.N. Ou S.P. Xiong X. Pan Y. Pei J. Xu R.C. Geng F.N. Han L. Zhang D.K. Yang M. Stems and leaves of Aconitum carmichaelii Debx. as potential herbal resources for treating rheumatoid arthritis: Chemical analysis, toxicity and activity evaluation. Chin. J. Nat. Med. 2018 16 9 644 652 10.1016/S1875‑5364(18)30104‑3 30269841
    [Google Scholar]
  59. Niu Y. Dong Q. Li R. Matrine regulates Th1/Th2 cytokine responses in rheumatoid arthritis by attenuating the NF‐κB signaling. Cell Biol. Int. 2017 41 6 611 621 10.1002/cbin.10763 28295853
    [Google Scholar]
  60. Qiu H. Sun S. Ma X. Cui C. Chen G. Liu Z. Li H. Liu M. Jatrorrhizine hydrochloride suppresses proliferation, migration, and secretion of synoviocytes in vitro and ameliorates rat models of rheumatoid arthritis in vivo. Int. J. Mol. Sci. 2018 19 5 1514 10.3390/ijms19051514 29783696
    [Google Scholar]
  61. Li L. Gu W.Y. Resveratrol-mediated tenascin-c/TLR4 signaling pathway regulating inflammatory reaction in RA rats. Western J. Tradit. Chin. Med 2020 33 20 23
    [Google Scholar]
  62. Wang X. Jiang L. He Y.L. Zheng L. Liu T. Dong L. Ma X. Li Y.J. Effect of caffeoylquinic acid from Periploca forrestii on anti-rheumatoid arthritis in vitro and its mechanism. Chin. Pharmacol. Bull 2018 34 1362 1367
    [Google Scholar]
  63. Liu Y. Duan X.Q. Yan F.L. Pan C. Wu J.C. Cao F. Liang J. Isochlorogenic acid A inhibits activation of NLRP3/NF-κB in rats with collagen-induced arthritis. Chin. Pharmacol. Bull. 2019 35 1415 1419
    [Google Scholar]
  64. Vashistha B. Sharma A. Jain V. Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination. Nutr. Neurosci. 2017 20 1 60 70 10.1179/1476830514Y.0000000165 25494651
    [Google Scholar]
  65. Zhu H. Liang Q. Xiong X. Wang Y. Zhang Z. Sun M. Lu X. Wu D. X., Dan Wu, D. Anti-inflammatory effects of coumaric acid, a natural compound of oldenlandia diffusa, on arthritis model rats. Evid. Based Complement. Alternat. Med. 2018 2018 1 5198594 10.1155/2018/5198594 29681976
    [Google Scholar]
  66. Wang W. Sun W. Jin L. Caffeic acid alleviates inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes by inhibiting phosphorylation of IκB kinase α/β and IκBα. Int. Immunopharmacol. 2017 48 61 66 10.1016/j.intimp.2017.04.025 28463788
    [Google Scholar]
  67. Wang Q. Zhou X. Zhao Y. Xiao J. Lu Y. Shi Q. Wang Y. Wang H. Liang Q. Polyphyllin I ameliorates collagen-induced arthritis by suppressing the inflammation response in macrophages through the NF-κB pathway. Front. Immunol. 2018 9 2091 10.3389/fimmu.2018.02091 30319603
    [Google Scholar]
  68. Pan S.H. Wang Y.P. Wang M.L. Zhang Y. Emodin could inhibit TNF-α-HIF-1α-iNOS-NO signaling pathway to reduce bone and cartilage tissue damage and prevent pannus formation in RA rats. Pharmacol. Clin. Chin. Mater. Med. 2019 35 62 67
    [Google Scholar]
  69. Zhu M. Yuan K. Lu Q. Zhu Q. Zhang S. Li X. Zhao L. Wang H. Luo G. Wang T. Huang G. Xu A. Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation. Mol. Immunol. 2019 112 188 197 10.1016/j.molimm.2019.05.010 31176198
    [Google Scholar]
  70. Miao C.G. Zhou G.L. Qin M.S. Chen J.Z. Li C.F. Effect of phellinus polysaccharide on canonical Wnt signaling in synovium in rats with rheumatoid arthritis. Sichuan Da Xue Xue Bao Yi Xue Ban 2015 46 3 376 379 26121856
    [Google Scholar]
  71. Wu D. Chen H. Jiang H. Zhang M.Q. Shi C.J. Jiao Y.Y. Wang P. Xu H.Y. Screening of active components and analysis of mechanism of dipsaci radix in treating rheumatoid arthritis based on UPLC-QTOF-MS/MS and TCMIP. Zhongguo Shiyan Fangjixue Zazhi 2021 27 131 140
    [Google Scholar]
  72. Liu C.X. Recognizing healthy development of traditional Chinese medicine industry from resources quality markers of traditional Chinese medicine. Chin. Tradit. Herbal Drugs 2016 47 3149 3154
    [Google Scholar]
  73. Wang M.Y. Yang Y. Zhou X.Y. Wang S.S. Duan S.X. Li X.B. The chemical constituents from Urtica fissa leaves. J. Asian Nat. Prod. Res. 2018 20 8 709 718 10.1080/10286020.2017.1383397 28971690
    [Google Scholar]
  74. Zhang H. Zhang Y. Wang M.Y. Chen S. Li X.B. The chemical constituents with cytotoxicity from Urtica fissa seed. J. Asian Nat. Prod. Res. 2019 21 11 1068 1074 10.1080/10286020.2018.1563074 30693804
    [Google Scholar]
  75. Zhang Y. Liu J.Z. Guo Z.X. Li X.B. Wang M.Y. Chemical constituents from urtica fissa stem and their inhibitory effects on α-glucosidase activity. Nat. Prod. Res. 2019 2019 1 7 31674849
    [Google Scholar]
  76. Tabekoueng G.B. Mvot Akak C. Langat M.K. Azebaze A.G.B. Waffo A.F.K. Choudhary M.I. Vardamides J.C. Chemical constituents from penianthus camerounensis dekker (menispermaceae). Z. Naturforsch. B. J. Chem. Sci. 2019 74 10 703 708 10.1515/znb‑2019‑0072
    [Google Scholar]
  77. Mou H. Cai H. The role of sinomenine in rheumatoid arthritis. Shanxi Med. J. 2012 41 1114 1115
    [Google Scholar]
  78. Liang Q. Yan R.H. Wang Y.H. Zhang J. Xue X.N. Li Y.Y. Toxicity and efficacy research about aqueous extract of Stephania tetrandra and Tetrandrine. Zhongguo Shiyan Fangjixue Zazhi 2015 21 163 166
    [Google Scholar]
  79. Lin X. Song F. Zhou L. Wang Z. Wei C. Xu J. Zhao J. Liu Q. Cepharanthine suppresses osteoclast formation by modulating the nuclear factor‐κB and nuclear factor of activated T‐cell signaling pathways. J. Cell. Biochem. 2019 120 2 1990 1996 10.1002/jcb.27495 30426543
    [Google Scholar]
  80. Zhu W.F. Zhou B. Guan Y.M. Liu R.H. Huang L.P. Zha Q.L. Zhao Y.P. Analysis of quality marker from Pueraria lobata. Zhonghua Zhongyiyao Xuekan 2019 37 775 777
    [Google Scholar]
  81. Ye H.D. Liu Y. Zhen P.C. Effect of atractylodin on mitochondrial autophagy in autophagy in rats with knee osteorthitis by regulating PINK1/Parkin signal pathway. Chin. J. Microcircution 2023 33 13 20
    [Google Scholar]
  82. Zhao C.Y. Mao X.X. Research progress on chemical components and pharmacological effects of Atractylodes macrocephala. J. Chengde Med. Coll. 2010 27 309 311
    [Google Scholar]
  83. Wu M.L. He Q.M. Yang F. Gao H. Xie Y.J. Analysis of the main active ingredients and pharmacological mechanisms of Stephania tetrandra based on network pharmacology. Chin. Arch. Tradit. Chin 2021 39 213 216
    [Google Scholar]
  84. Chen W.G. On the material foundation and side effects of traditional Chinese medicine taste from the chemical composition of 450 Chinese medicines. China Pharm 1995 2 46 47
    [Google Scholar]
  85. Li H. Hu H.Z. Research progress on the pharmacological effects of Plumbago zeylanica. Jilin Med. J. 2022 43 3095 3098
    [Google Scholar]
  86. Zhao C.B. 2016
  87. Xiao Y. Zhang H.R. Chen H. Gu Y.H. Hong H.Q. The effect of electroacupuncture on the pharmacokinetics and liver damage indicators of orally administered triptolide A in RA rats. J. Basic Clin. Med. 2017 23 1284 1287
    [Google Scholar]
  88. Tang L. Preliminary pharmacokinetic study of Zheng-Qing-Feng-Tong-Ning in AIA model rats and systematic review of its clinical efficacy in patients with Rheumatoid arthritis. 2020
    [Google Scholar]
  89. Zheng T.Y. 2018
  90. Wang W.L. Determination of artemisinin in rheumatoid arthritis capsules by HPLC. Chin. J. Basic Med. Tradit. Chin. Med 2003 9 43 47
    [Google Scholar]
  91. Deng X.H. Tan M.Y. Yao Y.H. Selection of active components treating rheumatoid arthritis by regulating TNF-α expression in Shenqi anti-inflammatory formula and their HPLC-ELSD simultaneous determination. Strait Pharm J 2020 32 58 61
    [Google Scholar]
  92. Zhang Y. 2013
  93. Wu D. 2013
  94. Zhang T.J. Bai G. Liu C.X. The concept, core theory and research methods of Chinese medicine quality markers. Yao Xue Xue Bao 2019 54 186 196
    [Google Scholar]
  95. Zhang M.Y. Ge W.H. Yao Y. The effect of alcohol extracts from Caulis sinomenii on articular bone destruction of rats with arthritis. Herald Med 2013 32 565 568
    [Google Scholar]
  96. Lin J. Yu H.M. Yu T. Effects of curcumin capsule with methotrexate on bone erosion in rheumatoid arthritis. Tianjin J. Tradit. Chin. Med 2019 36 238 241
    [Google Scholar]
  97. Yuan K. Mechanism study on the treatment of rheumatoid arthritis by regulating neutrophil activity with triptolide and celastrol. 2017
    [Google Scholar]
  98. Song X.M. Xu B. Zhang H.H. Liang R.F. The impact of total saponins of Achyranthes bidentata on Th17/Treg balance and IL-2, IL-6, TNF-α in synovial tissue of rheumatoid arthritis rats. Tradit. Chin. Med. Res 2020 33 70 73
    [Google Scholar]
  99. Chen K.M. Chen H. Wang C.Y. Liu J. Study on the effect of total flavonoids of Davallia mariesii on serum MMP-3, CD200, and IL-17 in high altitude RA secondary OP patients. J. Pract. Orthop 2017 23 711 714
    [Google Scholar]
  100. Xu H. Pan S.H. Wang Y.P. Sun Q.W. Li H.M. Wang M.L. Effect of Sabia parviflora ethanol extract on related proteins in rheumatoid arthritis rats. Pharmacol. Clin. Chin. Mater. Med. 2018 34 87 92
    [Google Scholar]
  101. Zhang Y.X. Wang J. Zhang Q.L. Wu G.T. Xia Q. Zhao L. The study of the therapeutic action of gentiopicroside in Gentiana officinalis on the osteoarthritis model rat. Zhong Yao Cai 2017 40 441 445
    [Google Scholar]
  102. Shen J. Zhang Y.X. Wu G.T. Xia P.F. Li Y. Zhao L. Study on the therapeutic effect of total iridoid glycosides in Gentiana officinalis macrophylla on a rat model of osteoarthritis. Pharmacol. Clin. Chin. Mater. Med 2018 34 85 89
    [Google Scholar]
  103. Chen L.F. Wu J. He D.C. Wu J.P. Research of Astragalus membranaceus injection and Ligusticum sinense injection in action mechanism of rheumatoid arthritis. J. Emerg. Tradit. Chin. Med 2012 21 924 925
    [Google Scholar]
  104. Li J. Yang H.L. Zhao X.X. Zhang L.Y. Research progress on the application of resveratrol in rheumatoid arthritis. Chin. J. Rheumatol 2020 24 488 491
    [Google Scholar]
  105. Yang X. Li Y.H. Qian H.B. Yang C.F. Molecular mechanism of ursolic acid against rheumatoid arthritis based on network pharmacology and molecular docking. Zhongguo Shiyan Fangjixue Zazhi 2018 24 207 214
    [Google Scholar]
  106. Su J. A randomized parallel controlled study on the treatment of rheumatoid arthritis with sustained-release sinomenine tablets combined with Western medicine. J. Pract. Tradit. Chin. Int. Med 2013 27 104 106
    [Google Scholar]
  107. Zeng M.X. Lv Z.Y. Li Y. Effects of Caulophyllum robustum Maxim extract on the proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis through NF-κB signaling pathway. J. Shenyang Med. Coll 2020 22 216 219
    [Google Scholar]
  108. Agu D.M. Chen W.W. Tang H.Y. Yao C.H. Huang H.P. Research progress of Tripterygium wilfordii in the treatment of rheumatoid arthritis. Liaoning Zhongyiyao Daxue Xuebao 2021 23 118 121
    [Google Scholar]
  109. Yang X. Wang L. The anti-inflammatory effect of Platycodon grandiflorus extract on rheumatoid arthritis rats. Xiandai Shipin Keji 2020 36 22 27
    [Google Scholar]
  110. Wang C.X. The therapeutic effect and mechanism of baicalin on rheumatoid arthritis model mice. 2019
    [Google Scholar]
  111. Liu L.Y. Mai Y.Y. Research progress in the treatment of rheumatoid arthritis with traditional Chinese medicine and its clinical application. Electro. J. Clin. Med. Lit 2020 7 195
    [Google Scholar]
  112. Ding Q. Nie H. He D.Y. Feng W. Immunological regulation mechanism of (-)-epigallocatechin-3-gallate on rheumatoid arthritis. Chin. J. Rheumatol 2011 8 526 530
    [Google Scholar]
  113. Li J.H. Ma J. Li J.C. Wang W. Shao Z.J. Wang Z.R. The effect of melittin on the affected joint of rheumatoid arthritis model rats. Med. J. Chin. People’s Armed Police Force 2011 22 741 743
    [Google Scholar]
  114. Li W. Zhang S.N. Effects of oxymatrine on immune balance and inflammation in patients with rheumatoid arthritis. China Mod. Med 2019 26 18 21
    [Google Scholar]
  115. Luo X.H. Zhou J. Hong X.Z. Mo H.Y. The therapeutic effect of Artemisia annua on refractory rheumatoid arthritis patients and its effect on TH17/Treg cytokines. Zhongguo Yiyuan Yaoxue Zazhi 2017 37 2451 2455
    [Google Scholar]
  116. Huang H. Study on the mechanism of the genistein inhibiting angiogenesis in rheumatoid arthritis. 2018
    [Google Scholar]
  117. Zhu G.H. Wang X.W. Qi C. Luan J.W. The regulatory effect of Astragalus total flavonoids on high glucose-induced inflammatory factors in HK-2 cells through miR-378. Immunol. J. 2019 35 653 658
    [Google Scholar]
  118. Liu X.M. Yu H. Research progress of gut microbiota in treatment of rheumatoid arthritis. Med. Recapitulate 2019 25 711 715
    [Google Scholar]
  119. Wei H. Zhao J.X. Liu X.Y. Research progress on the role of gut microbiota in the pathogenesis of rheumatoid arthritis. Zhonghua Yi Xue Za Zhi 2018 98 1723 1725
    [Google Scholar]
  120. Badsha H. Role of diet in influencing rheumatoid arthritis disease activity. Open Rheumatol. J. 2018 12 1 19 28 10.2174/1874312901812010019 29515679
    [Google Scholar]
  121. Chen X.Q. Huang X.J. Shi D.Y. Guo S.N. Research progress on interaction of Chinese materia medica with gut microbiota. Chin. Tradit. Herbal Drugs 2014 45 1031 1036
    [Google Scholar]
  122. Cui X.F. Du C.H. Pei X.P. Qin X.M. Yan Y. Investigation and predictive analysis on quality markers of Ziziphi Spinosae Semen based on human intestinal microbiota transformation. Chin. Tradit. Herbal Drugs 2019 50 4634 4642
    [Google Scholar]
  123. Yan M.Z. Yu J. Dong T.T. Zhou T.T. Chen G.T. Li S.G. Therapeutic effect of total saponins of Chaenomeles speciosa on K/BxN mouse serum-transfer arthritis via gut microbiota disturbance. Current Immunol 2020 40 265 271
    [Google Scholar]
  124. Liu J. Dong Q.M. Hao H. Wu H. Jia L.F. He B. Study on intestinal immune mechanisms of Terminalia chebula extract in CIA model rats. Zhonghua Zhongyiyao Xuekan 2020 38 35 39
    [Google Scholar]
  125. Liu C. Liu L. Guo D. Quality marker of TCMs: concept and applications. Phytomedicine 2018 44 85 86 10.1016/j.phymed.2018.05.015 29895496
    [Google Scholar]
  126. Li S. Exploring traditional chinese medicine by a novel therapeutic concept of network target. Chin. J. Integr. Med. 2016 22 9 647 652 10.1007/s11655‑016‑2499‑9 27145941
    [Google Scholar]
  127. Lv L. Yao X.Q. Yuan B. Huo L.Y. Xu Y.J. Research progress on oxidative on inflammatory response of rheumatoid arthritis. Acta. Chin. Med. 2024 39 1448 1453
    [Google Scholar]
/content/journals/cchts/10.2174/0113862073321827240918040737
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The Mechanisms and Quality Markers of Anti-rheumatoid Arthritis of Traditional Chinese Medicine
Bentham Science Publishers ; https://doi.org/10.2174/0113862073321827240918040737
/content/journals/cchts/10.2174/0113862073321827240918040737
/content/journals/cchts/10.2174/0113862073321827240918040737
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  • Article Type:     Review Article
Keywords: traditional Chinese medicine ; quality marker ; mechanism ; Rheumatoid arthritis

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