Current Chromatography - Volume 1, Issue 2, 2014

Chiral separation at nano scale is gaining importance in drugs development, proteomic, genomic and environmental sciences. Generally, traces of drugs are found in our body for several weeks. These cannot be detected by conventional analytical techniques. The present article discusses the advances in chiral resolution at nano scale using nano liquid chromatography (NLC) and nano capillary electrophoresis (NCE). The instru Read More

Ion chromatography was first introduced in 1975. Since then, it has been applied in most areas of the analytical chemistry. It is an effective technique used to analyze various inorganic and organic ions present in samples with different matrices. Importantly, ion chromatography has almost completely replaced the classical methods of ion determination. Its main advantages include: short analysis time; analysis of sm Read More

This article reviews the most recent and significant advances in headspace gas chromatography (HS-GC). The evolution and potential industrial applications in the last five years (2008 to present) are reviewed and discussed. The topics include a brief overview of the recent advances in HS-GC techniques and theory, followed by examples of new applications and instrumentation for the different headspace analysis technique Read More

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitary contaminants, which constitute a wide range of organic compounds. Many of them proved to be carcinogenic and mutagenic, produced mainly by industrial and non-industrial combustion processes, but also are present in water, air, soil, and as contaminants in foods, and beverages. Several industrial processes and artificial human activities can increase naturally environ Read More

Since the development of chiral stationary phases (CSPs), liquid chromatography has emerged as one of the most useful methods for analyses and preparation of enantiomerically pure bioactive compounds. However, the key for success of enantioseparation lies in the first place in the choice of a suitable CSP having enantioselectivity for the target enantiomers. Thus, this work describes a comparative study of resolution of seven Read More

A sensitive, precise and environmentally friendly stability indicating Rapid Resolution Liquid Chromatographic (RRLC) method for the determination of valaciclovir HCl in presence of its degradation products was developed and validated. An isocratic separation was achieved using Zorbax SB phenyl column with flow rate of 0.3 mL min-1 and UV detection at 254 nm. The mobile phase was a mixture of 0.01M n-tetrabutyl amm Read More