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2000
Volume 17, Issue 4
  • ISSN: 1568-0096
  • E-ISSN: 1873-5576

Abstract

Background: Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as “synthetic lethality”. Nowadays, synthetic lethality has become a widely used anti-cancer strategy. Method: We reviewed the synthetic lethal interactions exploited in anticancer therapies before 2016. Conclusion: Synthetic lethality is a well proved anticancer strategy and more synthetic lethal interactions is being translated into clinical cancer therapies.

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/content/journals/ccdt/10.2174/1568009616666160426122736
2017-05-01
2025-07-04
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