Antiangiogenic Therapeutic Approaches in Multiple Myeloma

Domenico Ribatti; Giuseppe Mangialardi; Angelo Vacca

doi:10.2174/156800912802429346

ISSN: 1568-0096
E-ISSN: 1873-5576

Antiangiogenic Therapeutic Approaches in Multiple Myeloma
By Domenico Ribatti, Giuseppe Mangialardi and Angelo Vacca
Source: Current Cancer Drug Targets, Volume 12, Issue 7, Sep 2012, p. 768 - 775
DOI: https://doi.org/10.2174/156800912802429346
- Available online: 01 Sep 2012

Abstract

Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and has prognostic potential. The pathophysiology of MM-induced angiogenesis involves both direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. An improved understanding of the importance of angiogenesis-related signaling in MM has allowed for the rational use of antiangiogenic therapies in this tumor. This review article summarizes the literature data concerning the employment of the most important antiangiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of MM.

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2012-09-01

2025-05-25

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Article Type: Research Article

Keyword(s): Angiogenesis; antiangiogenesis; bortezomib; chorioallantoic membrane; Hypoxia inducible factor 1 alpha; lenalinomide; Monoclonal gammopathy of undetermined significance; multiple myeloma; Platelet-derived growth factor receptor; thalidomide; thyrosine kinase inhibitors; zoledronic acid

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Antiangiogenic Therapeutic Approaches in Multiple Myeloma

Abstract

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