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2000
Volume 11, Issue 4
  • ISSN: 1568-0096
  • E-ISSN: 1873-5576

Abstract

The renin-angiotensin system (RAS) plays a critical role in the regulation of the cardiovascular system, and the RAS is present in various local organ systems. A retrospective cohort study raised the possibility of protection against cancer by the use of angiotensin converting enzyme (ACE) inhibitors. It has been reported that angiotensin II (Ang-II) is implicated in the development or invasion of several kinds of cancer tissue. There has recently been clinical evidence supporting the involvement of Ang-II in carcinogenesis. Continuously, several studies concerning the association between antihypertensive medication and cancer risk have been reported. This special issue of CCDT aims to provide an overview of important aspects on the cutting edge of RAS in cancer. Gallagher et al. focus on studies examining the RAS in pulmonary cancers and whether clinical intervention in this pathway may serve as an effective chemotherapeutic or chemopreventive modality for lung cancer. Ino et al. present the role of the RAS in the progression of gynecologic cancers and the clinical potential of blocking the RAS as a promising strategy for treatment. The review by Leung et al. appraises the current research progress on the role of the RAS in pancreatic cancer, and discusses the potential for developing drugs to target the RAS for treatment of pancreatic cancer. Ruiter et al. summarize the insertion/deletion polymorphism in the ACE gene in association with the risk of cancer and consequently on its potential role as therapeutic drug target in cancer. Yoshiji et al. concentrate upon the possible application of widely available agents, ACE inhibitor and/or angiotensin-II type I receptor blocker (ARB) against hepatocellular carcinoma as alternative agents in clinical practice. Uemura et al. present a potential role of the RAS in various aspects of prostate cancer, and useful treatment or chemoprevention by using ARBs for prostate cancer.

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/content/journals/ccdt/10.2174/156800911795538138
2011-05-01
2025-05-10
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  • Article Type:
    Research Article
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