Cancer Vaccines in Phase II/III Clinical Trials: State of the Art and Future Perspectives

S. Cecco; E. Muraro; E. Giacomin; D. Martorelli; R. Lazzarini; P. Baldo; R. Dolcetti

doi:10.2174/156800911793743664

ISSN: 1568-0096
E-ISSN: 1873-5576

Cancer Vaccines in Phase II/III Clinical Trials: State of the Art and Future Perspectives
By S. Cecco, E. Muraro, E. Giacomin, D. Martorelli, R. Lazzarini, P. Baldo and R. Dolcetti
Source: Current Cancer Drug Targets, Volume 11, Issue 1, Jan 2011, p. 85 - 102
DOI: https://doi.org/10.2174/156800911793743664
- Available online: 01 Jan 2011

Abstract

The topic of this review covers a very important branch of cancer research, cancer vaccination. The growing knowledge in tumor immunology has evolved rapidly, starting from unspecific generic stimulation of the immune system to more specific approaches based on the availability of tumor antigens. The review covers molecular and cell biology, and pharmaceutical technology of cancer vaccines. Particularly, it is aimed at highlighting the results of cancer vaccines from phase II and III clinical trials, an issue that is of relevance to better understand how cancer vaccines can successfully complement antitumor therapy, including conventional chemotherapy and the recently developed target-based drugs.

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2011-01-01

2025-05-10

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Article Type: Research Article

Keyword(s): adenocarcinoma; aluminium hydroxide; Alzheimer's; anti-tumor; antigen; anus; arthralgia; autoimmune disease; Bacteria; Belagenpumatucel-L; Brain; Breast Cancer; Cancer; CANCER VACCINES; carbohydrate; chemotherapy; clinical trials; constipation; dendritic cell (DC); DNA; dysplasias; dyspnoea; emulsion; endotoxin; eosinophils; exogenous agent; Food Drug Administration (FDA); Freund's complete adjuvant (FCA); gels; glioma; Granulocyte; growth factors; hepatitis B virus (HBV); Hepatocellular carcinoma (HCC); heterogeneity of enrolled patients; Hodgkin's Lymphoma; hormone-refractory prostate; hyperstimulation; immune system; immunotherapy; infectious disease; inflammatory mediators; interleukins; investigational drugs; lipid; liposomal vaccine; long-term memory immune responses; lung cancer; lymph node; lymphotoxic molecules; mammalian cells; Melanoma; memory cells; metastatic colorectal cancer; monocytes; monocytogenes; morbidity; mortality; mucin-1; Mycobacterium; neutrophils; oligodeoxinucleotide; oropharynx; orphan drug; pancreatic cancer; pandemic vaccines; papillomaviruses; pelvic discomfort; penis; phagocytic cells; pharmacological; Pharmexa; phospholipid; placebo; polymer microspheres; PROPHYLACTIC; Prostate Cancer; Protein; pyrexia; radiation therapy; Salmonella typhimurium; saponin; Shigella; surface active agents; surgery; symptomatic metastatic; Temozolomide; Therapeutic Vaccines; therapeutic vaccines; tumor cells; tumor-associated antigen; Vitespen; vulvar disease; Xenoantigens

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Cancer Vaccines in Phase II/III Clinical Trials: State of the Art and Future Perspectives

Abstract

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