Thomsen-Friedenreich Disaccharide Immunogenicity

Fernando J. Irazoqui; Gustavo A. Nores

doi:10.2174/1568009033481714

ISSN: 1568-0096
E-ISSN: 1873-5576

Thomsen-Friedenreich Disaccharide Immunogenicity
Authors: Fernando J. Irazoqui¹ and Gustavo A. Nores²
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¹ Ciquibic-Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina. ² Ciquibic-Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina.
Source: Current Cancer Drug Targets, Volume 3, Issue 6, Dec 2003, p. 433 - 443
DOI: https://doi.org/10.2174/1568009033481714
- Available online: 01 Dec 2003

Abstract

Mucin-type O-glycans are upregulated and aberrantly glycosylated in many carcinomas. O-glycan Core 1 (Galβ1-3GalNAcα-O-), also called Thomsen-Friedenreich disaccharide, is a cryptic structure overexpressed in cancer cells through modification of its glycosyltransferase profile. This molecule is a useful model for study of carbohydrate immunogenicity as well as a candidate for active specific immunotherapy of cancer patients. Several strategies are discussed for enhancing immune response to a particular region of carbohydrate: carbohydrate-protein conjugation, linkers, synthetic clustered sugars, chemical modifications, peptide / protein mimetics, and molecular rotation.

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2003-12-01

2025-05-22

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Article Type: Review Article

Keyword(s): carbohydrate-protein conjugation; glycosyltransferase; immunogenicity; molecular rotation; mucin-type o-glycans; o-glycan core 1; peptide/protein mimetics; synthetic clustered sugars; thomsen-friedenreich disaccharide

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Thomsen-Friedenreich Disaccharide Immunogenicity

Abstract

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