A Facile and Convenient Approach for the One-Pot Synthesis of Naphtho- 1,3-oxazine Derivatives

A protocol describes the synthesis of naphtha-1,3-oxaizine derivatives via one-pot multi-component reaction of α-naphthol, formaldehyde and various substituted anilines catalyzed by L-proline as an efficient catalyst. A method offers delightful advantages such as mild reaction conditions, environmentally benign, easy experimental workup and good to excellent yields.