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image of Efficacy Assessment of Sulfated Flavanol Functionalized Silver Nanoparticles against MCF-7 Breast Cancer

Abstract

Aim

The present research work aims to formulate a cost-effective and less toxic drug for specific and selective delivery at the tumor site.

Background

Existing therapeutics, such as chemo, surgery, etc., for fast-paced MCF-7 breast cancer, still face challenges, especially due to their toxic side effects. The unique properties of metal nanoparticles embedded in anti-oxidant plant polymers have sparked great interest in the formulation of less toxic-targeted drugs for cancer cure.

Objective

The present work aims to synthesize a targeted formulation of colloidal nanosilver by surface engineering of silver nanoparticles using plant polymers in electrolytic deposition technique, developed indigenously at the institute lab.

Methods

A current is passed through an elctrolyte, AgNO, which splits it into ions. The positive ions of Ag deposit over LDPE wrapped carbon cathode and negative ion, NO, is liberated. Ag+ ions get capped in-situ. These surface-modified silver nanoparticles formulate a colloidal solution. UV-visible and FTIR spectroscopy, TEM-EDX, and XRD were used to validate as-prepared formulation and in vivo human tumor xenograft model in NOD-SCID mouse for efficacy against MCF-7 breast cancer.

Results

The as-synthesized formulation consists of pure spherical poly-dispersed silver nanoparticles of average size 5.4 nm, coated with sulphated flavanols. The efficacy evaluation reported that it significantly, T/C = 0.53, reduced tumor volumes with a 100% survival rate and change in animal body weight <4 gms.

Conclusion

The as-synthesized formulation can be used as a potential neo-adjuvant or adjuvant drug along with existing therapeutics for MCF-7 breast cancer, significantly reducing the toxicity and cost.

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2024-12-02
2025-01-19

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/content/journals/ccand/10.2174/012212697X345534241121082505
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Efficacy Assessment of Sulfated Flavanol Functionalized Silver Nanoparticles against MCF-7 Breast Cancer
Bentham Science Publishers ; https://doi.org/10.2174/012212697X345534241121082505
/content/journals/ccand/10.2174/012212697X345534241121082505
/content/journals/ccand/10.2174/012212697X345534241121082505
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  • Article Type:     Research Article
Keywords: NOD-SCID ; XRD ; therapeutics ; MCF-7 ; TEM-EDX ; Cost-effective

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