Current Bioinformatics - Volume 19, Issue 2, 2024

Long non-coding RNAs (LncRNAs) are significant contributors to bacterial infections and host defense responses, presenting a novel class of gene regulators beyond conventional protein-coding genes. This narrative review aimed to explore the involvement of LncRNAs as a potential biomarker in the diagnosis and treatment of bacterial infections, with a specific focus on Brucella infections. A comprehensive literature review was Read More

Background: Breast tumor is among the most malignant tumors and early detection can improve patient's survival rate. Currently, mammography is the most reliable method for diagnosing breast tumor because of high image resolution. Because of the rapid development of medical and artificial intelligence techniques, computer-aided diagnosis technology can greatly improve the detection accuracy of breast tumors and Read More

Background: The oligometastatic disease has been proposed as an intermediate state between primary tumor and systemically metastatic disease, which has great potential curable with locoregional therapies. However, since no biomarker for the identification of patients with true oligometastatic disease is clinically available, the diagnosis of oligometastatic disease remains controversial. Objective: We aim to identif Read More

Background: Proteins and nucleic acids are vital biomolecules that contribute significantly to biological life. The precise and efficient identification of hot spots at protein-nucleic acid interfaces is crucial for guiding drug development, advancing protein engineering, and exploring the underlying molecular recognition mechanisms. As experimental methods like alanine scanning mutagenesis prove to be time-consuming and expen Read More

Background and Objective: Gene promoters play a crucial role in regulating gene transcription by serving as DNA regulatory elements near transcription start sites. Despite numerous approaches, including alignment signal and content-based methods for promoter prediction, accurately identifying promoters remains challenging due to the lack of explicit features in their sequences. Consequently, many machine learning Read More

Background: Metastasis involves multiple stages and various genetic and epigenetic alterations. MicroRNA has been investigated as a biomarker and prognostic tool in various cancer types and stages. Nevertheless, exploring the role of miRNA in kidney cancer remains a significant challenge, given the ability of a single miRNA to target multiple genes within biological networks and pathways. Objective: This study aims to propo Read More