s Umbelliferone Loaded Nanocarriers for Healthcare Applications

Background: Nanotechnology brings innovation in the healthcare sector and revolutionized the therapeutic domain in recent years. It provides better health facilities and bring advancement in the field of science and technology. Nanocarriers are extremely small structure and involve synthesis, designing, application of medicament in the size range of 1-100 nm. Nanocarriers are especially explored for their chemical, physical and biological activity. Good understanding of all these properties is necessary to increase the therapeutic application of nanocarriers in different fields, by abating the hazards to creatures and the environment. The goal of this article is to review the developed nanocarriers of Umbelliferone from the viewpoints of research trend, synthesis, targeting mechanism, its clinical applications and future perspective. Methods: A wide variety of nanocarriers system of umbelliferone have been developed, such as nanoshell, nanowire, nanoparticles, solid lipid nanostructure, dendrimers, nanoemulsion, nanosponges, etc. Nanosystem of umbelliferone is prepared by two approaches i.e. top-up and bottom down method, as well as their potential application in several areas, is presented in this paper. Results: Umbelliferone, a 7-hydroxycoumarin is widely available Rutaceae and Apiaceae families and termed as a therapeutic active agent. It is a derivative of coumarin and contain a heterocyclic ring with the improved biological property. In the literature survey, antifungal, antibacterial, antihyperglycaemic, anti-cancer, anti-diabetic, anti-arthritic, antioxidant and anti-inflammatory property are reported. Nanocarriers encapsulated umbelliferone have been recommended and explored to treat various types of diseases. Conclusion: This article upsurges the understanding of the nano-based delivery system of drug Umbelliferone in the field of biomedical application along with the safety concerns. A future perspective on the fabrication of nanocarriers of umbelliferone, scaling up technique, therapeutic efficacy and environmental protection is presented in the review. This advocates that numerous possible application of this drug for the future works are available for the commercialization.