Skip to content
2000
Volume 2, Issue 2
  • ISSN: 1874-6098
  • E-ISSN: 1874-6128

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder of central nervous system (CNS) that impaired the patient motor skills, speech and other functions. Adenosine A2A receptors have a unique cellular distribution in the neuron, which is used as a potential target for PD. Homology modeling was used to construct the 3-D structure of A2A using the known template (PDB: 2VT4), and the stereochemical quality was validated. Several effective antagonist drugs were selected and active amino acid residues in A2A were targeted on the basis of robust binding affinity between proteindrug interactions in molecular docking. Six antagonists, Bromocriptine, Cabergoline, Etilevodopa, Lysuride, Melevodopa and Pramipexole, were found more potent for binding and the active amino acids residues were identified (http://www.rcsb.org/pdb/) in A2A receptor. It could be used as the basis for rationale designing of novel antagonist drugs against Parkinson's diseas.

Loading

Article metrics loading...

/content/journals/cas/10.2174/1874609810902020127
2009-07-01
2025-01-19
Loading full text...

Full text loading...

/content/journals/cas/10.2174/1874609810902020127
Loading

  • Article Type:
    Research Article
Keyword(s): Adenosine A2A; antagonists; docking; homology modeling; Parkinson's disease
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test