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Apoptosis has been implicated in the pathogenesis of various neurodegenerative disorders, although the extent to which it is responsible for the neurodegeneration along with other kinds of cell death is of considerable controversy. To encapsulate arguments from all sides of this controversy, in this issue of Current Alzheimer Research, we have been fortunate to garnish some of the foremost thought leaders in the field to discuss the role of apoptosis in neurodegenerative disease. As is evident from the scholarly works of the authors, this area of research has attracted some of the most innovative research groups in the field and, as Editors, we are truly privileged that many of these investigators have contributed to this issue. We express our sincerest gratitude to the contributing authors as well as to the vision of the Editor-in-Chief, Dr. Debomoy Lahiri, for the opportunity provided by Current Alzheimer Research.