oa Erratum

Due to an oversight, the figure caption on the Contents page of Current Alzheimer Research, Volume 1, Number 4 was wrongly published. The corrected caption is reproduced as follows: The figure shown on the front cover of this journal was taken from the article entitled Amyloid b-Peptide: The Inside Story (pp. 231-239) by Bertrand P. Tseng, Masashi Kitazawa and Frank M. LaFerla. The slide shows a proposed model of the effects of intraneuronal amyloid b-peptide (Ab) on key neurobiological phenomena. Ab is proteolytically derived from the large Ab precursor protein (APP). Mutations in the presenilin genes also affect the formation of intracellular Ab which exists as monomers, oligomers or fibrils. The potential pathophysiolgical contribution of intracellular Ab accumulation includes synaptic dysfunction, proteasome dysfunction, calcium dyshomeostasis and tau hyperphosphorylation. The cell membrane is shown to separate extracellular and intracellular compartments.