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Volume 21, Issue 4
  • ISSN: 1567-2050
  • E-ISSN: 1875-5828

Abstract

Background

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, with a significant burden on global health. AD is characterized by a progressive cognitive decline and memory loss. Emerging research suggests a potential link between periodontitis, specifically the presence of oral bacteria such as (), and AD progression. produces an enzyme, Agmatine deiminase (AgD), which converts agmatine to N-carbamoyl putrescine (NCP), serving as a precursor to essential polyamines. Recent studies have confirmed the correlation between disruptions in polyamine metabolism and cognitive impairment.

Objective

This study aims to investigate the dysregulation of Agmatine deiminase (PgAgD) in the context of AD.

Methods

Saliva samples were collected from a total of 54 individuals, including 27 AD patients and 27 healthy controls. The expression of the gene was analyzed using quantitative Real-Time PCR.

Results

The results showed a significant decrease in gene expression in the saliva samples of AD patients compared to healthy controls. This downregulation was found in AD patients with advanced stages of periodontitis. Additionally, a correlation was observed between the decrease in expression and the 30-item Mini-Mental State Examination (MMSE) score.

Conclusion

These findings suggest that measuring expression in saliva could be a noninvasive tool for monitoring AD progression and aid in the early diagnosis of patients with periodontitis. Further research is needed to validate our results and explore the underlying mechanisms linking periodontitis, PgAgD expression, and AD pathophysiology.

© 2024 Bentham Science Publishers
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2024-04-01
2024-11-21

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/content/journals/car/10.2174/0115672050327009240808103542
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Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer’s Disease
Curr Alzheimer Res 21, 232 (2024); https://doi.org/10.2174/0115672050327009240808103542
/content/journals/car/10.2174/0115672050327009240808103542
/content/journals/car/10.2174/0115672050327009240808103542
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  • Article Type:     Research Article
Keyword(s): Alzheimer’s disease; arginine; Periodontitis; polyamines metabolism; Porphyromonas gingivalis; saliva

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