Polarographic Determination of Voriconazole in Pharmaceutical Formulations

This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.