O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids

Benedetto Natalini; Roccaldo Sardella; Roberto Pellicciari

doi:10.2174/1573411052948479

ISSN: 1573-4110
E-ISSN: 1875-6727

O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids
Authors: Benedetto Natalini¹, Roccaldo Sardella² and Roberto Pellicciari³
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Affiliations: ¹ Universita degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo 1, 06123 Perugia, Italy. ² Universita degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo 1, 06123 Perugia, Italy. ³ Universita degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo 1, 06123 Perugia, Italy.
Source: Current Analytical Chemistry, Volume 1, Issue 1, Jan 2005, p. 85 - 92
DOI: https://doi.org/10.2174/1573411052948479
- Available online: 01 Jan 2005

Abstract

O-Benzyl-(S)-serine is a new selector for chiral ligand-exchange chromatography which has proved to be effective in the analytical separation of some natural and unnatural underivatized amino acids with fair to good separation and resolution factors. Both chiral mobile phase (CMP) and hydrophobically coated chiral stationary phase (CSP) approaches were successfully employed. A not completely clarified mechanism of chiral recognition is discussed.

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2005-01-01

2024-11-26

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Article Type: Review Article

Keyword(s): chiral coated phase; chiral mobile phase; enantiomer separation; hydrophobically coated phase

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O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids

Abstract

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