Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents) - Volume 9, Issue 2, 2010

Background: We have recently reported that Lactobacillus GG (LGG) elaborates seven small peptides that exert both anti- Gram-negative and Gram-positive bactericidal activity. Among them, peptides NPSRQERR, VHTAPK and PDENK have higher activity than others. Here we further report the inhibitory function of these three peptides on antibiotic- resistant bacterial strains and preliminary structure-activity analysis. Method Read More

The work describes QSAR and SAR studies on the TIBO derivatives as non-nucleotide reverse transcriptase inhibitor of HIV-1 using the 2D-topological, physicochemical and hydrophobic parameters, indicator parameters along with the some 3D or quantum parameters. The set of TIBO derivatives chosen for the modeling is consists of 20 compounds. Application of multiple linear regression analysis indicated that a comb Read More

Tuberculosis (TB) has remained an enemy of humankind before the beginning of recorded history. Although it is curable and preventable, TB claims the lives of more than 5,000 people every day. Despite of availability of effective chemotherapy and BCG vaccine in 21st century, TB remains one of the most deadly infectious diseases. The concomitant resurgence of TB with the Multi-drug resistant (MDR) or Extremely drug resista Read More