Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) - Volume 21, Issue 3, 2022

Osteoarthritis is the most common human joint disease in the world. It is also one of the most common skeletal muscle defects, destructive joint changes, and the leading cause of disability and reduced quality of life. Destructive changes in inflammatory joints are associated with a range of biochemical events, including the overproduction of inflammatory cytokines. Cytokines are protein compounds that play an essential rol Read More

Background: The pathogenesis of Sjögren’s syndrome involves the activation of NF- ΚB, producing proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1α, IL- 1β, IL-6, IL-17, and interferon-γ. Through oxidative stress, they will cause necrosis and apoptosis of lacrimal gland cells, resulting in impaired secretory function or reduced tear production. Moringa oleifera leaf extract is known to have strong an Read More

Background: Chamaenerion latifolium is a perennial herbaceous plant of the Onagraceae family. The purpose of this study was to evaluate and compare the volatile chemical components of the aerial parts of Chamaenerion latifolium growing in the Republic of Kazakhstan. Methods: The leaves and stems of Chamaenerion latifolium were extracted with hexane and analysed by gas chromatography-mass spectrometry (GC Read More

Background: In traditional medicine, Linum usitatissimum treats inflammatory, gastrointestinal, and cardiovascular diseases. Objectives: The present study aims to assess the anti-inflammatory and anti-oxidant effects of total alkaloid extract from Linum usitatissimum seeds (ALU) on the ear histological integrity and oxidant- antioxidant status in a mice model of a sub-chronic inflammation induced by multiapplication of TP Read More

Aim: The in vitro effects of commonly used first-line anti-arthritic drugs on early stages of T-cell activation were examined. Methods: The 2B4.11 murine T cell hybridoma cell line recognizing pigeon cytochrome c (PCC) as the antigen was co-cultured with the histocompatible antigen presenting B cell hybridoma line LK35.2, PCC, and anti-arthritic drugs, including methotrexate, hydroxychloroquine, salazopyrine, cyclos Read More

Background: Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease in the world. It is known that there is a pathogenic relation between liver damage and the inflammatory and oxidative environment present in Metabolic Syndrome (MS). Objective: To study the pharmacological action of atorvastatin and metformin in an experimental model of MS. Methods: We used 40 male rats (Wista Read More