Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) - Volume 10, Issue 6, 2011

The present study is aimed at improving the dissolution of poorly soluble drug, rofecoxib, using solid dispersion technique. The solid dispersions were prepared in different proportions using hydrophilic carriers like mannitol, and urea. The dissolution rate studies were performed in both simulated gastric fluid and simulated intestinal fluid. It is observed that the dissolution was affected by the acidity of the medium. Solid di Read More

Extra virgin olive oil (EVOO) is consumed as part of the health promoting Mediterranean diet and contains several phenolic compounds that are responsible for the unique and distinctive flavour of EVOO. The phenolic fraction of EVOO also imparts many beneficial effects on human health. Oleocanthal is an EVOO phenolic that shares a unique perceptual quality with the non-steroidal anti-inflammatory drug (NSAID) ibuprofe Read More

In the last decade, substantial progress has been made in the study of eicosanoid autacoids, such as leukotrienes [LTs], which were already known to be heavily involved in inflammatory skin processes. The subject has extended from the detailed description of 5-lipoxygenase cascade products and regulation to the discovery of detailed interrelations among LT physiology and apparently loosely related fields such as peroxisome- Read More

Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several s Read More

Severe asthma developed into a major health problem since many patients suffering from this disease exhibit a high degree of resistance towards corticosteroid treatment. Thus, to date there is no effective therapy available, which frequently leads to hospitalization and necessity for critical care measurements including mechanic ventilation. While mild-to-moderate allergic asthma arises from a typical T helper 2 (TH2) cell di Read More

Objectives: Bioactivity guided fractionation of leaves of Vitex negundo for their anti-allergic and antioxidant activity and structure elucidation of active fraction responsible for these activities. Methods: Ethyl acetate fraction of leaves of Vitex negundo was fractionated into aqueous sub fraction, acetone sub fraction and chloroform sub fraction according to possible separation of chemical spots present in ethyl acetate fr Read More

In an attempt for better treatment of bacterial infections and burn wounds various topical formulations containing 1%w/w of Curcuma longa were prepared and evaluated for physical appearance, pH, rheological properties and stability studies. Antimicrobial activity of prepared formulations was found to be more effective against various strains of bacteria. Carbopol gel base is the most suitable dermatological base for Curcu Read More