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  3. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
  4. Volume 23, Issue 2
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Volume 23, Issue 2
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Over the years, researchers have endeavored to identify dependable and reproducible models for examining macrophage behavior under controlled conditions. The THP-1 cell line has become a significant and widely employed tool in macrophage research within these models. Originating from the peripheral blood of individuals with acute monocytic leukemia, this human monocytic cell line can undergo transformation into macrophage-like cells, closely mirroring primary human macrophages when exposed to stimulants. Macrophages play a vital role in the innate immune system, actively regulating inflammation, responding to infections, and maintaining tissue homeostasis. A comprehensive understanding of macrophage biology and function is crucial for gaining insights into immunological responses, tissue healing, and the pathogenesis of diseases such as viral infections, autoimmune disorders, and neoplastic conditions. This review aims to thoroughly evaluate and emphasize the extensive history of THP-1 cells as a model for macrophage research. Additionally, it will delve into the significance of THP-1 cells in advancing our comprehension of macrophage biology and their invaluable contributions to diverse scientific domains.

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2025-01-24

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/content/journals/aiaamc/10.2174/0118715230294413240415054610
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Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) 23, 85 (2024); https://doi.org/10.2174/0118715230294413240415054610
/content/journals/aiaamc/10.2174/0118715230294413240415054610
/content/journals/aiaamc/10.2174/0118715230294413240415054610
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  • Article Type:     Review Article
Keyword(s): acute monocytic leukemia; homeostasis; in vitro models; macrophage research; peripheral blood; THP-1

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