Applied Clinical Research, Clinical Trials and Regulatory Affairs - Volume 3, Issue 3, 2016

Background: Generic drugs are those that are identical or bioequivalent to a brand name drug or innovator drug in active ingredient(s), dosage form, strength, route of administration, intended use, quality, safety and performance characteristics. Pharmaceutical companies need to submit Abbreviated New Drug Application (ANDA) to the US Food and Drug Administration (FDA) for approval to market a generic product in the Read More

Down syndrome (DS) is a genetic disorder characterized by the presence of three chromosomes instead of two, specifically chromosome No. 21. The special needs status of DS individuals makes them more prone to several medical conditions such as congenital heart disease, gastrointestinal tract anomalies, immunodeficiency, visual impairment, skeletal defects, audiological dysfunction, seizures, acute leukaemia and thyroid Read More

5-Fluorouracil (5-FU) is a principal chemotherapeutic agent for treatment of a variety of malignant diseases. The standard method for dosing of 5-FU has been based on body surface area. Significant variation of plasma levels of 5-FU among individuals has been shown to influence the clinical outcomes. Accumulating data suggest that area under the concentration versus time curve (AUC)-based dosing of 5-FU improves the cli Read More

Systems for organizing specific data about large groups of people have been in existence for many years; their structures depend greatly on their purposes and goals. This paper describes the creation of a registry and database detailing demographics and co-occurring conditions of a population with Down syndrome living in the United Arab Emirates. The Gulf Down Syndrome Registry-Abu Dhabi seeks to describe the p Read More

Introduction: Hepatitis C virus (HCV) commonly causes chronic liver disease. The majority of the countries in the Middle East have intermediate or high endemicity of HCV. Adequate knowledge, attitude and behavior, are critical to decline the spread of this infection. In this study, we aim to assess the level of knowledge and attitude of medical and health science students in Ras Al Khaimah (RAK), United Arab Emirates (UAE), Read More

Chronic pain is prevalent and significantly disrupts functioning. One current theory suggests that chronic pain is influenced by systemic inflammation. Altered eating (AE) has been shown to improve chronic pain by reducing inflammation; however it is necessary to consider practicality and compliance in a real world setting. Objectives: Evaluate the response and practicality of an educational AE program on p Read More

Background: Age related Macular Degeneration (AMD) is one of the leading causes of blindness that leads to an irreversible loss of vision among elderly population. The prevalence of AMD in India is likely to increase due to high population growth and increased life expectancy of the individuals. The epidemiology of AMD in India is similar to those found in developed countries. Materials and Methods: A pilot study base Read More

Background: Abusive alcohol consumption is a public healthcare problem all across the world, carrying a heavy toll of almost 6% of all deaths. Nearly 5% of the world population makes use of illicit drugs frequently. The treatment for patients with any substance abuse disorder, whether it is alcohol or another drug, requires specialized view. The purpose of this research was to characterize a group of users at a Psychosocial C Read More