Applied Clinical Research, Clinical Trials and Regulatory Affairs - Volume 3, Issue 1, 2016

Objective: To study and critically analyze the published evidence on use of metformin for different indications during pregnancy through a systematic review and to provide background for its use through a narrative review. Data sources and Selection of the studies: PubMed, CENTRAL, Embase, SCIENCE DIRECT were searched up to March 2015. Medical subject handling terms (MeSH) and free text term key words like m Read More

Background: In developing countries such as Zambia, couples seldom make decisions with regard to fertility solely in consultation with each other. At all stages of family formation couples are strongly persuaded by cultural and social norms. In additions couples are influenced by opinions and information provided by close friends and relatives in couple’s social net works. Social net works play an important role in enabling husb Read More

Background: Tooth wear or tooth surface loss is a common finding that has been recently increasingly associated with the pediatric population. Many factors can contribute to this condition. Aim of the Study: To determine the prevalence of tooth wear and identify possible risk factors in the primary dentition of Abu Dhabi, UAE, school children. Methods: This cross-sectional study examined 506 children aged 2.6-6.8 years. De Read More

Background: Child mortality rates remain stubbornly high in many parts of India. One reason for the high child mortality rates is related to breast feeding practices. Less than one third of the mothers breastfeed within half an hour of birth in urban areas and only one fifth do so in the rural areas. When mothers either delay or do not breastfeed at all, the likelihood of child mortality rate increases. While urban - rural differen Read More

Background: Health status is important for the all age groups particularly for the elderly who mostly suffer from chronic illnesses, progressive disabilities and ailments. Socio-economic status, however, has been known as a significant determinant for health of both communities and individuals. Indeed further information about the effects of socio-economic factors on the health of the elderly would be helpful for decis Read More

Background: Microsponges is a class of polymeric microspheres that are porous and are aimed to deliver a pharmaceutically active constituent competently at the smallest dose and also, to alter release of the drug. Objective: The aim of the present work was to formulate a topical gel based drug delivery system of microsponges containing Celecoxib (CXB). Method: Quasi emulsion solvent diffusion method was used to prepar Read More

Objective: The aim of the present study was to formulate fast disintegrating sublingual tablet of Timolol maleate (TM) for the potential emergency treatment of hypertension and also its potential to circumvent the first-pass metabolism and to improve its bioavailability. The demand of fast disintegrating sublingual tablet has been growing mainly for geriatric because of potential emergency treatment. Methods: The tablets Read More