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2000
Volume 21, Issue 5
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Background: Chalcones are structurally simple compounds that are easily accessible by synthetic methods. Heterocyclic chalcones have gained the interest of scientists due to their diverse biological activities. The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications dealing with this topic warrants an up-to-date compilation. Methods: Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as common web-based literature searching tools. Pertinent and current literature was covered from 2015/2016 to 2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones are summarized. Results: Simply prepared chalcones have emerged over the last years with promising antitumor activities. Among them, there are a considerable number of tubulin polymerization inhibitors. But there are also new chalcones targeting special enzymes such as histone deacetylases or with DNA-binding properties. Conclusion: This review provides a summary of recent heterocyclic chalcone derivatives with distinct antitumor activities.

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/content/journals/acamc/10.2174/1871520620666200705215722
2021-03-01
2025-06-01
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  • Article Type:
    Review Article
Keyword(s): anticancer agents; Chalcone; drug design; heterocycle; histone deacetylase; tubulin
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