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- ISSN: 1871-5206
- E-ISSN: 1875-5992
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Bruton Kinase Inhibitors in Chronic Lymphocytic Leukemia
- Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Volume 17, Issue 8, Jul 2017, p. 1040 - 1045
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- 01 Jul 2017
Abstract
Abnormality of the B-cell receptor (BCR) signaling is correlated to origin of many B-cell malignancies. Bruton’s tyrosine kinase (BTK), is described as a possible target in a many B-cell neoplasms. Ibrutinib is the most used inhibitor of BTK and has great tolerability and efficacy in chronic lymphocytic leukemia. This review summarizes results with ibrutinib in clinical trials and novel BTK inhibitors of interest.
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