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- ISSN: 1871-5206
- E-ISSN: 1875-5992
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Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel
- Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Volume 16, Issue 7, Jul 2016, p. 875 - 880
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- 01 Jul 2016
Abstract
Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.
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