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2000
Volume 16, Issue 12
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

A novel synthetic method of 4-substituted aryl-1H-1,2,3-triazoles from arylglyoxaldoxime semicarbazone with sodium dithionite and O2 was found to be safer than the Huisgen azide– alkyne dipolar cycloaddition. A total of 17 new structures of 4-substituted aryl-1H-1,2,3- triazoles were characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro antihepatoma activities were evaluated on human hepatoma QGY-7703, Bel-7402 and SMMC-7721 cell lines and mouse fibroblast cells L-929 by MTS assay. Among them, 5k exhibited excellent activity against QGY-7703 (GI50 = 0.0232 μM), while 5p and 5q displayed good activity (GI50 = 0.103 μM and GI50 = 0.182 μM) against the growth of SMMC-7721 cell lines. Furthermore, 5k, 5p and 5q showed slight selectivity of inhibition on hepatoma cell lines over normal cell line L-929.

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/content/journals/acamc/10.2174/1871520616666151123095646
2016-12-01
2025-05-10
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  • Article Type:
    Research Article
Keyword(s): 2; 3-triazoles; 4-aryl-1H-1; anti-hepatoma activity; O2; sodium dithionite; Synthesis
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