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- ISSN: 1871-5206
- E-ISSN: 1875-5992
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Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor
- Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Volume 15, Issue 10, Dec 2015, p. 1305 - 1307
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- 01 Dec 2015
Abstract
4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
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