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2000
Volume 15, Issue 6
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic nude mice inoculated with HTC-116-luc2 cells prolonged their survival and greatly inhibited tumour growth, near to disappearance. Low concentration of gold in urine and blood were detected in mice after 48 h of administration of 5 mg/kg body weight (bw) of the gold complex and non-organ (kidney and liver) damage has been detected after gold treatment. The results obtained suggested that the thiolate gold(I) derivative shown here could be considered as a candidate for therapeutic treatment in colon cancer.

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/content/journals/acamc/10.2174/1871520615666150129211440
2015-07-01
2025-07-06
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/content/journals/acamc/10.2174/1871520615666150129211440
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  • Article Type:
    Research Article
Keyword(s): Apoptosis; colon cancer; gold(I); histopathology; in vivo; PTA; Thiolate
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