Skip to content
2000
Volume 15, Issue 5
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Azetidin-2-one, a β -lactam four-membered heterocyclic ring is widely identified for its diverse medicinal properties. Ezetimibe a cholesterol absorption inhibitor and Aztreonam a potent cephalosporinase inhibitor proved the medicinal value of azetidin-2-ones. On the other hand marine bromopyrrole alkaloids are well known for their diverse biological significance. Hence twenty novel conjugates of azetidin-2-ones integrated with 4,5-dibromopyrrole motif were synthesized and screened for antineoplastic activity using MTT assay. Synthesized hybrids displayed good antineoplastic profile particularly towards breast cancer cell line MCF7, where hybrid 5e displayed maximum cytotoxicity (IC50 = 0.5 µM). The selective cytotoxicity displayed by these conjugates towards tested cancer cells with non-toxicity against normal human VERO cells indicated their potential for further antineoplastic drug development.

Loading

Article metrics loading...

/content/journals/acamc/10.2174/1871520614666141203124745
2015-06-01
2025-07-08
Loading full text...

Full text loading...

/content/journals/acamc/10.2174/1871520614666141203124745
Loading

  • Article Type:
    Research Article
Keyword(s): Antineoplastic; azetidinone; bromopyrrole alkaloid; natural product
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test