Skip to content
2000
Volume 14, Issue 8
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

During the last five decades, enormous advances in treatment modalities for cancer and a better understanding of cancer cell biology have been accomplished but the prognosis of patients carrying malignant gliomas still remains poor despite hundreds of clinical trials have been carried out. In this article we review phase II clinical trials that have been completed and published in PubMed during 2011 in order to investigate potential reasons of clinical failure. We suggest that a translational gap, defined as a failure to translate basic research into clinical trials design may explain the poor outcome of phase II clinical trials.

Loading

Article metrics loading...

/content/journals/acamc/10.2174/1871520614666140825110907
2014-10-01
2025-05-10
Loading full text...

Full text loading...

/content/journals/acamc/10.2174/1871520614666140825110907
Loading

  • Article Type:
    Research Article
Keyword(s): Clinical trial; Glioma; phenotype; stem cell theory; stem cells; stemness
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test