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  3. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
  4. Volume 12, Issue 7
  5. Article
Volume 12, Issue 7
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedifferentiation of hepatoma cells. It introduces the reports on anti-cancer agents in the field of MMP science, and finally describes novel strategies for the early stages of HCC in relation to cancer stem cells.

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/content/journals/acamc/10.2174/187152012802650165
2012-09-01
2025-04-01

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  • Article Type:     Research Article
Keyword(s): Alcoholic liver diseases; Anti-cancer agents; Bone marrow-derived stem cell; Cancer invasion; Cancer metastasis; cancer stem cell; Cancer treatment; Hepatitis B virus (HBV); Hepatitis C virus (HCV); Hepatocellular carcinoma (HCC); Matrix metalloproteinase (MMP); Non-alcoholic liver diseases; Tissue inhibitor of metalloproteinase (TIMP)

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