Skip to content
2000
Volume 12, Issue 1
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Over the past decade, fragment-based drug discovery has developed significantly and has gained increasing popularity in the pharmaceutical industry as a powerful alternative and complement to traditional high-throughput screening approaches for hit identification. Fragment-based methods are capable of rapidly identifying starting points for structure-based drug design from relatively small libraries of low molecular weight compounds. The main constraints are the need for sensitive methods that can reliably detect the typically weak interactions between fragments and the target protein, and strategies for transforming fragments into higher molecular weight drug candidates. This approach has recently been validated as series of compounds from various programs have entered clinical trials.

Loading

Article metrics loading...

/content/journals/acamc/10.2174/187152012798764660
2012-01-01
2025-01-05
Loading full text...

Full text loading...

/content/journals/acamc/10.2174/187152012798764660
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test