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- ISSN: 1871-5206
- E-ISSN: 1875-5992
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A Computational View of COX-2 Inhibition
- Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Volume 6, Issue 3, May 2006, p. 239 - 249
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- 01 May 2006
Abstract
Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.
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