Pyrimidine and Pyrimidinone Derivatives as Anti-Inflammatory Agents
- Authors: Versha1, G. B. Dharma Rao2, Ravi Kumar Rana3, Anjaneyulu Bendi4
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View Affiliations Hide AffiliationsAffiliations: 1 Department of Chemistry, Baba Masthnath University, Rohtak 124001, Haryana, India 2 Department of Humanities and Sciences, Kommuri Pratap Reddy Institute of Technology, Ghanpur, Hyderabad-500088, India 3 Department of Chemistry, Baba Masthnath University, Rohtak-124001, Haryana, India 4 Department of Chemistry, Presidency University, Rajanukunte, Itgalpura, Bangalore-560064, Karnataka, India
- Source: Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists , pp 1-25
- Publication Date: May 2024
- Language: English
Pyrimidine and Pyrimidinone Derivatives as Anti-Inflammatory Agents, Page 1 of 1
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Heterocyclic compounds are one of the most significant sources of bioactive molecules. Pyrimidines and pyrimidinones are a class of nitrogen-containing heterocyclic compounds with significant biological activities. Among the different applications of these compounds in medicinal chemistry, their anti-inflammatory activities have attracted the attention of the scientific community to explore their chemistry. Some of these derivatives have been found to inhibit the production of proinflammatory cytokines and chemokine enzymes, which are involved in the recruitment and activation of immune cells at sites of inflammation. The chapter outlines the range of methods available to create different pyrimidine and pyrimidinone derivatives along with their anti-inflammatory activities.<br>
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