The endoplasmic reticulum (ER) is a sub-cellular organelle that is responsible for the correct folding of proteins lipid biosynthesis calcium storage and various post-translational modifications. In the disturbance of ER functioning unfolded or misfolded proteins accumulate inside the ER lumen and initiate downstream signaling called unfolded protein response (UPR). The UPR signaling pathway is involved in lipolysis triacylglycerol synthesis lipogenesis the mevalo Read More

It is possible that gut bacteria may have a beneficial effect on cardiovascular health in humans. It may play a major role in the progression of a variety of cardiovascular diseases including Heart Failure (HF) Atherosclerosis Coronary Arterial Disease (CAD) Ischemic Heart Disease (IHD) and Others. Dysbiosis of the gut microbiota along with its direct and indirect impact on gut health may induce cardiovascular disorders. Although advanced studies have de Read More

Despite intense research in the field of glioblastoma multiforme (GBM) therapeutics the resistance against approved therapy remains an issue of concern. The resistance against the therapy is widely reported due to factors like clonal selection involvement of multiple developmental pathways and majorly defective mismatch repair (MMR) protein and functional O6- methylguanine DNA methyltransferase (MGMT) repair enzyme. Phytotherapy is one o Read More

Diabetes is a series of metabolic disorders that can be categorized into three types depending on different aspects associated with age at onset intensity of insulin resistance and beta- cell dysfunction: Type 1 and 2 Diabetes and Gestational Diabetes Mellitus. Type 2 Diabetes Mellitus (T2DM) has recently been found to account for more than 85% of diabetic cases. The current review intends to raise awareness among clinicians/researchers that combinin Read More

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which genetic and environmental factors are involved in disease onset. Although by definition the disease is considered idiopathic in nature evidence-based studies have indicated familial cases of pulmonary fibrosis in which genetic factors contribute to IPF pathogenesis. Methods: Both common as well as rare genetic variants are associated with sporadic as well as fa Read More

The emergence of enantioselective organocatalysis as a potent synthetic chemistry strategy that supports metal-catalyzed transformations has resulted in the creation of novel procedures for the synthesis of various chiral molecules. Organocatalysis is a desirable method for creating complex molecular structures due to its many benefits including its ease of use wide availability of catalysts and low toxicity. Chemists are actively exploring synthetic Read More

Aims: The Isocyanides based Multi-component reactions (IMCRs) and Passerini reactions were performed by using GaCl3 and PEG-400 media to generate a library of new scaffolds. Background: The Isocyanides Multi-component reactions (IMCRs) have proven their importance due to their major advantages in synthetic and medicinal areas. Among various IMCRs Passerini stands for their pertinency in the novel adducts articulation and generates an amid Read More

Aims: The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation. Background: Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2). Objective: This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an ex vivo approach. Materials and Methods: In the current investigation the inhibitory effect of L-tartaric acid on di Read More