Elevated Levels of Soluble Fibrin in Patients with Thrombosis or a Pre- Thrombotic State

Background: Soluble fibrin (SF) is considered to be useful for the diagnosis of thrombosis, however, evidence for the diagnosis of pre-thrombosis by SF is still not well established. Objective: The present study was designed to evaluate the usefulness of new SF assay (New SF) in the diagnosis of thrombosis and a pre-thrombotic state. Patients/Methods: The plasma concentrations of New SF were measured in 748 inpatients suspected to have thrombosis and they correlated with thrombosis. Results and Conclusions: The plasma concentrations of New SF were significantly higher in patients with disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and cerebral thrombosis, in comparison to those of patients without thrombosis, but there was no significant difference of the New SF assay between patients with thrombosis and those after an operation. The New SF assay was moderately correlated with the other two SF assays. The New SF levels were significantly higher in patients before the onset of thrombosis than in those without thrombosis but other hemostatic molecular markers were not significantly elevated. Our findings suggest that the New SF assay is useful for the diagnosis of not only thrombosis but also of a pre-thrombotic state.