Skip to content
2000
Volume 8, Issue 2
  • ISSN: 1574-891X
  • E-ISSN: 2212-4071

Abstract

Coronaviruses have been thrust into the spotlight by the recurring novel human coronavirus infections following the 2003 SARS pandemic. In the years since the initial SARS outbreak, the arsenal to fight this virus family has been significantly increased by the rapid growth of coronavirus research. Among the potential viral drug targets, coronavirus 3C like proteases (3Cl) have emerged as the most popular drug target. A number of patented inhibitors with promising clinical potential have been developed via different methods of drug discovery, including virtual screening, natural product isolation and structure assisted rational drug design. This review serves as a summary of the progress in both the method of drug discovery and the related inhibitors against the coronavirus 3Cl protease.

Loading

Article metrics loading...

/content/journals/pri/10.2174/1574891X113089990017
2013-08-01
2025-01-09
Loading full text...

Full text loading...

/content/journals/pri/10.2174/1574891X113089990017
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test