The Anabolic Effects of Growth Hormone (GH) and GH Secretagogues on Bone Mass and Density

Several antiresorptive agents have been developed for the treatment of osteoporosis and bone disorders. Few agents have been introduced that stimulate bone formation. Treatment with parathyroid hormone induces, however, a potent increase in hip and lumbar bone mineral density (BMD) and is now available in some countries. The present review focuses on growth hormone (GH) / GH secretagogues (GHSs). GH / GHSs stimulates bone turnover, thereby increasing bone mass and density.