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Volume 22, Issue 3
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In the current study, we reported a cost-effective, simple strategy for the synthesis and reactivity of a novel series of chromenopyridine derivatives involving 2,4-diamino-3-carbonitrile moieties. These new compounds were synthesized in good yields from malononitrile and various chromene derivatives as a precursor, which was prepared by the reduction of iminocoumarin derivatives. The formed iminocoumarin was obtained by Knoevenagel condensation from malononitrile and different aromatic aldehydes. These novel chromenopyridine derivatives were further reacted with triethyl orthoformate under microwave irradiation to afford the final compounds, namely “chromenopyridine formimidate.” The structures of all molecules were characterized by FT-IR, 1H NMR, 13C NMR, and elemental analysis.

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2024-08-06
2025-04-06

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/content/journals/loc/10.2174/0115701786316461240801065332
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Microwave-assisted Synthesis and Reactivity of Some Novel Chromenopyridine Derivatives Bearing 2,4-Diamino-3-Carbonitrile Moieties
Letters in Organic Chemistry 22, 215 (2025); https://doi.org/10.2174/0115701786316461240801065332
/content/journals/loc/10.2174/0115701786316461240801065332
/content/journals/loc/10.2174/0115701786316461240801065332
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  • Article Type:     Research Article
Keyword(s): 1D NMR; Chromenopyridine derivatives; chromenopyridine formimidate; elemental analysis; microwave irradiation; triethyl orthoformate

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