Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents) - Current Issue

Background: In present decades, interest in tetrazole chemistry has been increasing rapidly because of its broad range of biological applications, primarily due to the role played by tetrazole in medicinal chemistry as this moiety offer a more complimentary pharmacokinetic profile and a metabolically stable substitute for carboxylic acid functionalities. The heterocyclic tetrazole moiety has admirable biological, pharmaceu Read More

Background: Insulin resistance is a frequent metabolic disorder in Polycystic Ovary Syndrome (PCOS). Moringa oleifera has been shown to increase insulin expression and decrease the degree of insulin in diabetes mellitus, therefore it is expected that Moringa oleifera could decrease insulin levels and increase folliculogenesis in PCOS. Objective: To prove the effect of Moringa oleifera leaf extract in various doses might decrea Read More

Background: Homeostasis of blood glucose concentration is a physiological phenomenon that is tightly regulated in humans and acts as a major cellular mechanism that decreases blood glucose during insulin-stimulated glucose transport. GLUT4 assumes a significant role in managing entire body glucose homeostasis. Recent research has found that overexpression of GLUT4 reduces glucose intolerance and diabetes. Interesti Read More

Background: The metabolic syndrome unites three pathologies of the person – obesity, arterial hypertension and diabetes. In recent years the progressing of such distribution covering from 2.5% to 3.8% of the population with increase twice each 10-15 years is noted. Even at maintenance of level of sugar at diabetes accumulation of the secondary metabolites breaking small vessels isn't excluded. At the same time many lif Read More

Background and Aims: To our knowledge, no study has investigated neither how Moringa leaf extract modulates the immune system in normal nor diabetic subjects. Materials and Methods: Diabetes was induced by a single intraperitoneal dose of alloxan (150 mg/kg). A dose of 100 mg/kg of MO extract was orally administered to diabetic treated mice. The profile of glucose and insulin was evaluated. The activity of superoxide dis Read More

Background: Despite its key role in the treatment, major abdominal surgery has been indicated as a cause of a metabolic, neuroendocrine and immunological response. Several studies have demonstrated that the magnitude of this postoperative Systemic Inflammatory Response (SIR) is directly associated with the development of complications after colorectal surgery. Objective: The aim of the present study was to invest Read More

Background: This research was performed to investigate the effects of prostaglandins on the sexual functions of albino male rats. The effects of prostaglandins on LH, FSH, testosterone secretion and semen quality of the male rats were investigated. PGE1 induced a significant decline in the level of LH, FSH and testosterone levels. PGE1 also induced significant decline in the testis, epididymal and seminal vesicle weights. Conc Read More

Background: Chronic and non-communicable diseases such as non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis, obesity, diabetes, cardiovascular dysfunctions, renal insufficiency, alcoholism and other inflammation disorders often lead to severe organ damage. Fibrosis, on the contrary, is a complex phenomenon that may turn into critical conditions if not treated properly. Several biochemical pathways and sign Read More

Background: Lactoferrin is a multifunctional protein found in breast milk. We previously reported the anti-obesity effects of enteric-coated lactoferrin (eLF). Objective: As the previous study included some subjects with high Body Mass Index (BMI) or low-Density Lipoprotein cholesterol (LDL-Cho), we investigated the antiobesity effect of lactoferrin excluding those subjects. Method: We conducted a subgroup analysis of a Read More