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image of Cytokine and Oxidative Stress Imbalances in Relation to Complex Coronary Lesions in Elderly Patients

Abstract

Background

Complex coronary lesions have been an understudied aspect of coronary artery disease in elderly patients. Oxidative stress and inflammation may be implicated in the pathogenesis of complex coronary lesions.

Objective

The aim of this study is to investigate the complex interplay between pro-oxidative stress response, pro-inflammatory response, and complex coronary lesions in elderly patients.

Methods

Enzyme-linked immunosorbent assays for the detection of serum biomarkers [reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), superoxide dismutase (SOD) activity, total antioxidant capacity (TAC), transforming growth factor beta (TGF-β) and interleukin-4 (IL-4)] were performed in elderly patients with complex coronary lesions.

Results

The levels of pro-oxidative stress and pro-inflammatory markers (ROS, MDA, TNF-α and IFN-γ) were increased in the complex coronary lesion group when compared with the non-complex coronary lesion group ( < 0.01) in elderly patients. Anti-oxidative stress and anti-inflammatory markers (SOD activity, TAC, TGF-β, and IL-4) were decreased in the complex coronary lesion group when compared with the non-complex coronary lesion group ( < 0.01) in elderly patients.

Conclusion

Our findings suggest that the pathogenesis of complex coronary lesions may involve pro-oxidant/anti-oxidant and pro-inflammation/anti-inflammation imbalance, as well as the interplay between oxidative stress and inflammation in elderly patients.

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2025-02-11
2025-05-05

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References

  1. Violi F. Pignatelli P. Valeriani E. Oxidative stress and atherosclerosis: Basic and clinical open issues. Kardiol. Pol. 2024 82 7-8 689 691 10.33963/v.phj.100994 38845438
    [Google Scholar]
  2. Morales-Villegas E. Coronary atherosclerosis the implications of being a woman. Curr. Hypertens. Rev. 2014 9 4 297 309 10.2174/1573402110666140702092016 24993280
    [Google Scholar]
  3. Montarello N.J. Nguyen M.T. Wong D.T.L. Nicholls S.J. Psaltis P.J. Inflammation in coronary atherosclerosis and its therapeutic implications. Cardiovasc. Drugs Ther. 2022 36 2 347 362 10.1007/s10557‑020‑07106‑6 33170943
    [Google Scholar]
  4. Libby P. Pasterkamp G. Crea F. Jang I.K. Reassessing the mechanisms of acute coronary syndromes. Circ. Res. 2019 124 1 150 160 10.1161/CIRCRESAHA.118.311098 30605419
    [Google Scholar]
  5. Goldstein J.A. Mehta N.K. Extent of coronary atherosclerosis and ischemic myocardium foment sudden cardiac death. Catheter. Cardiovasc. Interv. 2022 99 3 812 813 10.1002/ccd.30130 35235687
    [Google Scholar]
  6. Swirski F.K. Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 2013 339 6116 161 166 10.1126/science.1230719 23307733
    [Google Scholar]
  7. Gramlich Y. Daiber A. Buschmann K. Oelze M. Vahl C.F. Münzel T. Hink U. Oxidative stress in cardiac tissue of patients undergoing coronary artery bypass graft surgery: The effects of overweight and obesity. Oxid. Med. Cell. Longev. 2018 2018 1 6598326 10.1155/2018/6598326 30647815
    [Google Scholar]
  8. Salvatore T. Galiero R. Caturano A. Vetrano E. Loffredo G. Rinaldi L. Catalini C. Gjeloshi K. Albanese G. Martino D.A. Docimo G. Sardu C. Marfella R. Sasso F.C. Coronary microvascular dysfunction in diabetes mellitus: Pathogenetic mechanisms and potential therapeutic options. Biomedicines 2022 10 9 2274 10.3390/biomedicines10092274 36140374
    [Google Scholar]
  9. Daien V. Carriere I. Kawasaki R. Cristol J.P. Villain M. Fesler P. Ritchie K. Delcourt C. Retinal vascular caliber is associated with cardiovascular biomarkers of oxidative stress and inflammation: The POLA study. PLoS One 2013 8 7 e71089 10.1371/journal.pone.0071089 23923054
    [Google Scholar]
  10. Mishra P. Samanta L. Oxidative stress and heart failure in altered thyroid States. ScientificWorldJournal 2012 2012 1 17 10.1100/2012/741861 22649319
    [Google Scholar]
  11. Jakubiak G.K. Osadnik K. Lejawa M. Kasperczyk S. Osadnik T. Pawlas N. Oxidative stress in association with metabolic health and obesity in young adults. Oxid. Med. Cell. Longev. 2021 2021 1 9987352 10.1155/2021/9987352 34257828
    [Google Scholar]
  12. Jakubiak G.K. Osadnik K. Lejawa M. Osadnik T. Goławski M. Lewandowski P. Pawlas N. “Obesity and insulin resistance” is the component of the metabolic syndrome most strongly associated with oxidative stress. Antioxidants 2021 11 1 79 10.3390/antiox11010079 35052583
    [Google Scholar]
  13. Arida A. Protogerou A.D. Kitas G.D. Sfikakis P.P. Systemic inflammatory response and atherosclerosis: The paradigm of chronic inflammatory rheumatic diseases. Int. J. Mol. Sci. 2018 19 7 1890 10.3390/ijms19071890 29954107
    [Google Scholar]
  14. Salazar G. NADPH oxidases and mitochondria in vascular senescence. Int. J. Mol. Sci. 2018 19 5 1327 10.3390/ijms19051327 29710840
    [Google Scholar]
  15. Zhu Z. Li J. Zhang X. Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway. BMC Complement. Altern. Med. 2019 19 1 111 10.1186/s12906‑019‑2526‑4 31146723
    [Google Scholar]
  16. Asadi A. Yaghobi Nezhad D. Rafiei Javazm A. Khanicheragh P. Mashouri L. Shakeri F. Abbasi M. Afrazian M.S. Niknam Z. Abazari O. In vitro effects of curcumin on transforming growth factor-β-mediated non-smad signaling pathway, oxidative stress, and pro-inflammatory cytokines production with human vascular smooth muscle cells. Iran. J. Allergy Asthma Immunol. 2020 19 1 84 93 10.18502/ijaai.v19i1.2421 32245324
    [Google Scholar]
  17. Sudar Milovanovic E. Gluvic Z. Obradovic M. Zaric B. Isenovic E.R. Tryptophan metabolism in atherosclerosis and diabetes. Curr. Med. Chem. 2022 29 1 99 113 10.2174/0929867328666210714153649 34269660
    [Google Scholar]
  18. Fukai T. Ushio Fukai M. Superoxide dismutases: Role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal. 2011 15 6 1583 1606 10.1089/ars.2011.3999 21473702
    [Google Scholar]
  19. Othman Z.A. Zakaria Z. Suleiman J.B. Ghazali W.S.W. Mohamed M. Anti-atherogenic effects of orlistat on obesity-induced vascular oxidative stress rat model. Antioxidants 2021 10 2 251 10.3390/antiox10020251 33562069
    [Google Scholar]
  20. Panahipour L. Tabatabaei A.A. Gruber R. Hypoallergenic infant formula lacks transforming growth factor beta activity and has a lower anti-inflammatory activity than regular infant formula. J. Dairy Sci. 2020 103 8 6771 6781 10.3168/jds.2019‑18067 32505409
    [Google Scholar]
  21. Kedong H. Wang D. Sagaram M. An H.S. Chee A. Anti-inflammatory effects of interleukin-4 on intervertebral disc cells. Spine J. 2020 20 1 60 68 10.1016/j.spinee.2019.06.025 31265894
    [Google Scholar]
  22. Choi K.H. Song Y.B. Lee J.M. Lee S.Y. Park T.K. Yang J.H. Choi J.H. Choi S.H. Gwon H.C. Hahn J.Y. Impact of intravascular ultrasound-guided percutaneous coronary intervention on long-term clinical outcomes in patients undergoing complex procedures. JACC Cardiovasc. Interv. 2019 12 7 607 620 10.1016/j.jcin.2019.01.227 30878474
    [Google Scholar]
  23. Li X. Guo D. Hu Y Chen Y Evaluation of oxidative status in elderly patients with multiple cerebral infarctions and multiple chronic total coronary occlusions. Dis Markers 2022 2022 1 11 10.1155/2022/2083990 35801004
    [Google Scholar]
  24. Grodecki K. Cadet S. Staruch A.D. Michalowska A.M. Kepka C. Wolny R. Pregowski J. Kruk M. Debski M. Debski A. Michalowska I. Slomka P.J. Witkowski A. Dey D. Opolski M.P. Noncalcified plaque burden quantified from coronary computed tomography angiography improves prediction of side branch occlusion after main vessel stenting in bifurcation lesions: Results from the CT-PRECISION registry. Clin. Res. Cardiol. 2021 110 1 114 123 10.1007/s00392‑020‑01658‑1 32385529
    [Google Scholar]
  25. Lee D.H. Thiruvengadam S.K. Mohammed M. Goli R. Thiemann D. Lawson B.D. Resar J.R. Mohanty B.D. Efficacy of coronary computed tomography angiography for the de novo detection of chronic total occlusion prior to coronary angiography: A preliminary and retrospective study. Int. J. Angiol. 2020 29 4 223 228 10.1055/s‑0040‑1716328 33268972
    [Google Scholar]
  26. López-Palop L.R. Carrillo P. Cordero A. Frutos A. Mateo I. Mashlab S. Roldán J. Effect of lesion length on functional significance of intermediate long coronary lesions. Catheter. Cardiovasc. Interv. 2013 81 4 E186 E194 10.1002/ccd.24459 22511556
    [Google Scholar]
  27. Rzeszutko Ł. Siudak Z. Tokarek T. Plens K. Włodarczak A. Lekston A. Ochała A. Gil R.J. Balak W. Dudek D. Twelve months clinical outcome after bioresorbable vascular scaffold implantation in patients with stable angina and acute coronary syndrome. Postepy Kardiol. Interwencyjnej 2016 2 2 108 115 10.5114/aic.2016.59360 27279869
    [Google Scholar]
  28. Tomoi Y. Soga Y. Okazaki J. Iida O. Shiraki T. Hiramori S. Ando K. Drug-coated stent implantation vs. bypass surgery for in-stent occlusion after femoropopliteal stenting. Heart Vessels 2021 36 5 646 653 10.1007/s00380‑020‑01740‑8 33392645
    [Google Scholar]
  29. Ragosta M. Left main coronary artery disease: Importance, diagnosis, assessment, and management. Curr. Probl. Cardiol. 2015 40 3 93 126 10.1016/j.cpcardiol.2014.11.003 25765453
    [Google Scholar]
  30. Temov K. Sun Z. Coronary computed tomography angiography investigation of the association between left main coronary artery bifurcation angle and risk factors of coronary artery disease. Int. J. Cardiovasc. Imaging 2016 32 S1 Suppl. 1 129 137 10.1007/s10554‑016‑0884‑2 27076223
    [Google Scholar]
  31. Zhou YX Han WW Song DD Effect of miR-10a on sepsis-induced liver injury in rats through TGF-β1/Smad signaling pathway. Eur. Rev. Med. Pharmacol. Sci. 2020 24 2 862 10.26355/eurrev202001_20070
    [Google Scholar]
  32. Sáenz-Medina J. Martinez M. Rosado S. Durán M. Prieto D. Carballido J. Urolithiasis develops endothelial dysfunction as a clinical feature. Antioxidants 2021 10 5 722 10.3390/antiox10050722 34064366
    [Google Scholar]
  33. Aggarwal R. Jain A.K. Mittal P. Kohli M. Jawanjal P. Rath G. Association of pro‐ and anti‐inflammatory cytokines in preeclampsia. J. Clin. Lab. Anal. 2019 33 4 e22834 10.1002/jcla.22834 30666720
    [Google Scholar]
  34. Liu J. Gao L. Zang D. Elevated levels of IFN-γ in CSF and serum of patients with amyotrophic lateral sclerosis. PLoS One 2015 10 9 e0136937 10.1371/journal.pone.0136937 26332465
    [Google Scholar]
  35. Asadi S. Rahimi Z. Saidijam M. Shabab N. Goodarzi M.T. Effects of resveratrol on FOXO1 and FOXO3 a genes expression in adipose tissue, serum insulin, insulin resistance and serum SOD activity in type 2 diabetic rats. Int. J. Mol. Cell. Med. 2018 7 3 176 184 10.22088/IJMCM.BUMS.7.3.176 31565649
    [Google Scholar]
  36. Yaghoubi N. Youssefi M. Jabbari Azad F. Farzad F. Yavari Z. Zahedi Avval F. Total antioxidant capacity as a marker of severity of COVID‐19 infection: Possible prognostic and therapeutic clinical application. J. Med. Virol. 2022 94 4 1558 1565 10.1002/jmv.27500 34862613
    [Google Scholar]
  37. Khan S.A. Joyce J. Tsuda T. Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay. BMC Res. Notes 2012 5 1 636 10.1186/1756‑0500‑5‑636 23151377
    [Google Scholar]
  38. Eini P. Majzoobi M.M. Ghasemi Basir H.R. Moosavi Z. Moradi A. Comparison of the serum level of interleukin‐4 in patients with brucellosis and healthy controls. J. Clin. Lab. Anal. 2020 34 7 e23267 10.1002/jcla.23267 32100374
    [Google Scholar]
  39. Neglia D. Rovai D. Caselli C. Pietila M. Teresinska A. Bruix A.S. Pizzi M.N. Todiere G. Gimelli A. Schroeder S. Drosch T. Poddighe R. Casolo G. Anagnostopoulos C. Pugliese F. Rouzet F. Guludec L.D. Cappelli F. Valente S. Gensini G.F. Zawaideh C. Capitanio S. Sambuceti G. Marsico F. Filardi P.P. Golfín F.C. Rincón L.M. Graner F.P. Graaf d.M.A. Fiechter M. Stehli J. Gaemperli O. Reyes E. Nkomo S. Mäki M. Lorenzoni V. Turchetti G. Carpeggiani C. Marinelli M. Puzzuoli S. Mangione M. Marcheschi P. Mariani F. Giannessi D. Nekolla S. Lombardi M. Sicari R. Scholte A.J.H.A. Zamorano J.L. Kaufmann P.A. Underwood S.R. Knuuti J. Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Circ. Cardiovasc. Imaging 2015 8 3 e002179 10.1161/CIRCIMAGING.114.002179 25711274
    [Google Scholar]
  40. Price R.S. Kasner S.E. Hypertension and hypertensive encephalopathy. Handb. Clin. Neurol. 2014 119 161 167 10.1016/B978‑0‑7020‑4086‑3.00012‑6 24365295
    [Google Scholar]
  41. Eisen A. Harrington R.A. Stone G.W. Steg P.G. Gibson C.M. Hamm C.W. Price M.J. Prats J. Deliargyris E.N. Mahaffey K.W. White H.D. Bhatt D.L. Cangrelor compared with clopidogrel in patients with prior myocardial infarction – Insights from the CHAMPION trials. Int. J. Cardiol. 2018 250 49 55 10.1016/j.ijcard.2017.10.006 29030140
    [Google Scholar]
  42. Real A. Ukogu C. Krishnamoorthy D. Zubizarreta N. Cho S.K. Hecht A.C. Iatridis J.C. Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics. Spine J. 2019 19 2 225 231 10.1016/j.spinee.2018.05.035 29859349
    [Google Scholar]
  43. Kloner R.A. Chaitman B. Angina and its management. J. Cardiovasc. Pharmacol. Ther. 2017 22 3 199 209 10.1177/1074248416679733 28196437
    [Google Scholar]
  44. Songnuy T. Scholand S.J. Panprayoon S. Effects of tobacco smoke on aeroallergen sensitization and clinical severity among university students and staff with allergic rhinitis. J. Environ. Public Health 2020 2020 1 7 10.1155/2020/1692930 33101424
    [Google Scholar]
  45. Liang J. Olsen R.W. Alcohol use disorders and current pharmacological therapies: The role of GABAA receptors. Acta Pharmacol. Sin. 2014 35 8 981 993 10.1038/aps.2014.50 25066321
    [Google Scholar]
  46. Duval C. Müller M. Kersten S. PPARα and dyslipidemia. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2007 1771 8 961 971 10.1016/j.bbalip.2007.05.003 17604218
    [Google Scholar]
  47. Cheng X.M. Hu Y.Y. Yang T. Wu N. Wang X.N. Reactive oxygen species and oxidative tress in vascular-related diseases. Oxid. Med. Cell. Longev. 2022 2022 1 11 10.1155/2022/7906091 35419169
    [Google Scholar]
  48. Hameister R. Kaur C. Dheen S.T. Lohmann C.H. Singh G. Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty. J. Biomed. Mater. Res. B Appl. Biomater. 2020 108 5 2073 2087 10.1002/jbm.b.34546 31898397
    [Google Scholar]
  49. Buczyńska A. Sidorkiewicz I. Rogucki M. Siewko K. Adamska A. Kościuszko M. Maliszewska K. Kozłowska G. Szumowski P. Myśliwiec J. Dzięcioł J. Krętowski A. Popławska-Kita A. Oxidative stress and radioiodine treatment of differentiated thyroid cancer. Sci. Rep. 2021 11 1 17126 10.1038/s41598‑021‑96637‑5 34429481
    [Google Scholar]
  50. Capuzzi E. Ossola P. Caldiroli A. Auxilia A.M. Buoli M. Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry 2022 113 110469 10.1016/j.pnpbp.2021.110469 34740710
    [Google Scholar]
  51. Jelic M.D. Mandic A.D. Maricic S.M. Srdjenovic B.U. Oxidative stress and its role in cancer. J. Cancer Res. Ther. 2021 17 1 22 28 10.4103/jcrt.JCRT_862_16 33723127
    [Google Scholar]
  52. Calvani N.E.D. De Marco Verissimo C. Jewhurst H.L. Cwiklinski K. Flaus A. Dalton J.P. Two distinct superoxidase dismutases (SOD) secreted by the helminth parasite fasciola hepatica play roles in defence against metabolic and host immune cell-derived reactive oxygen species (ROS) during growth and development. Antioxidants 2022 11 10 1968 10.3390/antiox11101968 36290692
    [Google Scholar]
  53. Pudlarz A.M. Ranoszek-Soliwoda K. Czechowska E. Tomaszewska E. Celichowski G. Grobelny J. Szemraj J. A study of the activity of recombinant mn-superoxide dismutase in the presence of gold and silver nanoparticles. Appl. Biochem. Biotechnol. 2019 187 4 1551 1568 10.1007/s12010‑018‑2896‑y 30284207
    [Google Scholar]
  54. Musazadeh V. Jafarzadeh J. Keramati M. Zarezadeh M. Ahmadi M. Farrokhian Z. Ostadrahimi A. Flaxseed oil supplementation augments antioxidant capacity and alleviates oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Evid. Based Complement. Alternat. Med. 2021 2021 1 9 10.1155/2021/4438613 34527059
    [Google Scholar]
  55. Çalapkorur S. Besagil P.S. Şahin H. Determination of the relationship between total antioxidant capacity and dietary antioxidant intake in obese patients. Niger. J. Clin. Pract. 2020 23 4 481 488 10.4103/njcp.njcp_212_19 32246654
    [Google Scholar]
  56. Xue Y. Zeng X. Tu W.J. Zhao J. Tumor necrosis factor- α: The next marker of stroke. Dis. Markers 2022 2022 1 8 10.1155/2022/2395269 35265224
    [Google Scholar]
  57. Zelová H. Hošek J. TNF-α signalling and inflammation: Interactions between old acquaintances. Inflamm. Res. 2013 62 7 641 651 10.1007/s00011‑013‑0633‑0 23685857
    [Google Scholar]
  58. Kann O. Almouhanna F. Chausse B. Interferon γ: A master cytokine in microglia-mediated neural network dysfunction and neurodegeneration. Trends Neurosci. 2022 45 12 913 927 10.1016/j.tins.2022.10.007 36283867
    [Google Scholar]
  59. Karki R. Sharma B.R. Tuladhar S. Williams E.P. Zalduondo L. Samir P. Zheng M. Sundaram B. Banoth B. Malireddi R.K.S. Schreiner P. Neale G. Vogel P. Webby R. Jonsson C.B. Kanneganti T.D. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell 2021 184 1 149 168.e17 10.1016/j.cell.2020.11.025 33278357
    [Google Scholar]
  60. Huo R. Tian X. Chang Q. Liu D. Wang C. Bai J. Wang R. Zheng G. Tian X. Targeted inhibition of β-catenin alleviates airway inflammation and remodeling in asthma via modulating the profibrotic and anti-inflammatory actions of transforming growth factor-β 1. Ther. Adv. Respir. Dis. 2021 15 1753466620981858 10.1177/1753466620981858 33530899
    [Google Scholar]
  61. Ferreira R.R. Waghabi M.C. Bailly S. Feige J.J. Moreno H.A.M. Saraiva R.M. Jorge A.T.C. The search for biomarkers and treatments in chagas disease: Insights from TGF-beta studies and immunogenetics. Front. Cell. Infect. Microbiol. 2022 11 767576 10.3389/fcimb.2021.767576 35186778
    [Google Scholar]
  62. Lutgens E. Gijbels M. Smook M. Heeringa P. Gotwals P. Koteliansky V.E. Daemen M.J.A.P. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler. Thromb. Vasc. Biol. 2002 22 6 975 982 10.1161/01.ATV.0000019729.39500.2F 12067907
    [Google Scholar]
  63. Ji Z. Jiang X. Li Y. Song J. Chai C. Lu X. Neural stem cells induce M2 polarization of macrophages through the upregulation of interleukin‑4. Exp. Ther. Med. 2020 20 6 148 10.3892/etm.2020.9277 33093886
    [Google Scholar]
  64. Daseke M.J. II Tenkorang-Impraim T.M.A.A. Ma Y. Chalise U. Konfrst S.R. Garrett M.R. Pennell D.K.Y. Lindsey M.L. Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction. J. Mol. Cell. Cardiol. 2020 145 112 121 10.1016/j.yjmcc.2020.06.006 32574573
    [Google Scholar]
  65. Amaral E.P. Vinhaes C.L. Oliveira-de-Souza D. Nogueira B. Akrami K.M. Andrade B.B. The interplay between systemic inflammation, oxidative stress, and tissue remodeling in tuberculosis. Antioxid. Redox Signal. 2021 34 6 471 485 10.1089/ars.2020.8124 32559410
    [Google Scholar]
  66. Dharshini L.C.P. Rasmi R.R. Kathirvelan C. Kumar K.M. Saradhadevi K.M. Sakthivel K.M. Regulatory components of oxidative stress and inflammation and their complex interplay in carcinogenesis. Appl. Biochem. Biotechnol. 2023 195 5 2893 2916 10.1007/s12010‑022‑04266‑z 36441404
    [Google Scholar]
  67. Vallée A. Neuroinflammation in schizophrenia: The key role of the WNT/β-catenin pathway. Int. J. Mol. Sci. 2022 23 5 2810 10.3390/ijms23052810 35269952
    [Google Scholar]
  68. Vorpahl M. Virmani R. Ladich E. Finn A.V. Vascular remodeling after coronary stent implantation. Minerva Cardioangiol. 2009 57 5 621 628 10.3390/ijms23052810 19838152
    [Google Scholar]
  69. Shi P. Ji H. Zhang H. Yang J. Guo R. Wang J. circANRIL reduces vascular endothelial injury, oxidative stress and inflammation in rats with coronary atherosclerosis. Exp. Ther. Med. 2020 20 3 2245 2251 10.3892/etm.2020.8956 32765701
    [Google Scholar]
  70. Assar D.H. Elhabashi N. Mokhbatly A.A.A. Ragab A.E. Elbialy Z.I. Rizk S.A. Albalawi A.E. Althobaiti N.A. Jaouni A.S. Atiba A. Wound healing potential of licorice extract in rat model: Antioxidants, histopathological, immunohistochemical and gene expression evidences. Biomed. Pharmacother. 2021 143 112151 10.1016/j.biopha.2021.112151 34507115
    [Google Scholar]
  71. Huang H. Saddala M.S. Lennikov A. Mukwaya A. Fan L. RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGF-β) signaling. Mol. Cell. Biochem. 2020 475 1-2 93 106 10.1007/s11010‑020‑03862‑z 32813141
    [Google Scholar]
  72. Chleilat E. Pethe A. Pfeifer D. Krieglstein K. Roussa E. TGF-β signaling regulates SLC8A3 expression and prevents oxidative stress in developing midbrain dopaminergic and dorsal raphe serotonergic neurons. Int. J. Mol. Sci. 2020 21 8 2735 10.3390/ijms21082735 32326436
    [Google Scholar]
  73. Basaranoglu M. Basaranoglu G. Sentürk H. From fatty liver to fibrosis: A tale of “second hit”. World J. Gastroenterol. 2013 19 8 1158 1165 10.3748/wjg.v19.i8.1158 23483818
    [Google Scholar]
  74. Ni B. Shen H. Wang W. Lu H. Jiang L. TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway. J. Orthop. Surg. Res. 2019 14 1 241 10.1186/s13018‑019‑1260‑4 31358027
    [Google Scholar]
  75. Cutolo M. Campitiello R. Gotelli E. Soldano S. The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis. Front. Immunol. 2022 13 867260 10.3389/fimmu.2022.867260 35663975
    [Google Scholar]
  76. Prud’homme G.J. Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 2007 87 11 1077 1091 10.1038/labinvest.3700669 17724448
    [Google Scholar]
  77. Szondy Z. Sarang Z. Kiss B. Garabuczi É. Köröskényi K. Anti-inflammatory mechanisms triggered by apoptotic cells during their clearance. Front. Immunol. 2017 8 909 10.3389/fimmu.2017.00909 28824635
    [Google Scholar]
  78. Jimi S. Jaguparov A. Nurkesh A. Sultankulov B. Saparov A. Sequential delivery of cryogel released growth factors and cytokines accelerates wound healing and improves tissue regeneration. Front. Bioeng. Biotechnol. 2020 8 345 10.3389/fbioe.2020.00345 32426341
    [Google Scholar]
  79. Frangogiannis N.G. The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev. Cardiol. 2014 11 5 255 265 10.1038/nrcardio.2014.28 24663091
    [Google Scholar]
  80. Frangogiannis N.G. Transforming growth factor-β in myocardial disease. Nat. Rev. Cardiol. 2022 19 7 435 455 10.1038/s41569‑021‑00646‑w 34983937
    [Google Scholar]
  81. Jia M. Li Q. Guo J. Shi W. Zhu L. Huang Y. Li Y. Wang L. Ma S. Zhuang T. Wang X. Pan Q. Wei X. Qin Y. Li X. Jin J. Zhi X. Tang J. Jing Q. Li S. Jiang L. Qu L. Osto E. Zhang J. Wang X. Yu B. Meng D. Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation. Circ. Res. 2022 130 7 1038 1055 10.1161/CIRCRESAHA.121.319540 35196865
    [Google Scholar]
  82. Harvey E. Ramji D. Interferon-γ and atherosclerosis: Pro- or anti-atherogenic? Cardiovasc. Res. 2005 67 1 11 20 10.1016/j.cardiores.2005.04.019 15907820
    [Google Scholar]
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Cytokine and Oxidative Stress Imbalances in Relation to Complex Coronary Lesions in Elderly Patients
Bentham Science Publishers ; https://doi.org/10.2174/0115701611323165250211045917
/content/journals/cvp/10.2174/0115701611323165250211045917
/content/journals/cvp/10.2174/0115701611323165250211045917
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  • Article Type:     Research Article
Keywords: Cytokines ; coronary lesions ; oxidative stress ; elderly

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