Current Topics in Medicinal Chemistry - Online First

Introduction Alzheimer's disease (AD) is a prominent neurodegenerative ailment characterized by the constraints of conventional therapies stemming from insufficient medication transport to the brain. This review examines the function of polymeric nanocarriers (PNCs) in improving therapeutic efficacy for Alzheimer's disease treatment. Methods We analyze the principal obstacles to Alzheimer's disease drug delivery: Read More

Diabetes is a highly common chronic disorder of the endocrine system that affects 529 million people globally. Dysfunction of β-cells, impaired insulin secretion, and hyperactive α-cells are the primary reasons for this disease. Conventional therapy might fail since some drugs require specific conditions to achieve their maximum efficacy. Metallopharmaceutics is defined as the branch of pharmaceutics in which the activity of a Read More

Alzheimer is a progressive neurodegenerative disease characterized by change in brain that led to the buildup of specific proteins, ultimately causing brain shrinkage and the death of brain cells. It is the leading cause of dementia, manifesting as a gradual decline in memory, cognitive abilities, behavior, and social functioning, which severely impairs a person’s ability to carry out daily activities. The complexity of Alzheim Read More

The field of drug design has evolved from conventional approaches relying on empirical evidence to advanced approaches such as Computer-Aided Drug Design (CADD). It aids in intricate phases of drug discovery, such as target discovery, lead optimization, and clinical trials, establishing a safe, rapid, and cost-effective system. Structure based drug design (SBDD), Ligand based drug design (LBDD), and Pharmacophore modelling, Read More

Thiazole, a five-membered heterocycle containing sulfur and nitrogen, is a pivotal component in the design and synthesis of organic derivatives. Its prevalence in natural sources and its integral role in the structure of drug molecules has made it a focal point for researchers. In this study, we compiled and reviewed research from the past decade and categorized the synthesized thiazole compounds into three groups (di-substi Read More

Introduction The medicinal plants of Izki hold significant ethnopharmacological relevance, serving as primary healthcare resources for generations. These plants exhibit known pharmacological properties, making them crucial for traditional and modern therapeutic applications. Objectives The primary goal of this study was to record, conserve, and analyze the traditional knowledge of medicinal plants in Izki. It also aimed to eva Read More

Aim To investigate the antimicrobial potential of methanol fruit extract of Solanum xanthocarpum against Methicillin-Resistant Staphylococcus aureus (MRSA) and elucidate its mode of action. Background The rise of antimicrobial resistance (AMR) demands the exploration of alternative therapeutic strategies to combat resistant pathogens. Objective To evaluate the efficacy of Solanum xanthocarpum methanol extract ag Read More

Background This review is delving into determining the content and significance of hypericin, a pharmacologically important constituent commonly known as St. John's Wort (SJW). The paper explores the rich history of Hypericin's traditional use in alternative medicine and the recent surge in scientific interest surrounding its bioactive properties. Objective This review aims to provide a comprehensive analysis the therapeutic p Read More

Introduction CCN6/WISP3 is a member of the CCN adipokines family that can exert multiple effects on metabolic pathways. So far, the function of CCN6 in the pathogenesis of NAFLD has not been known well. Hence, we aimed to examine CCN6 serum levels in patients with NAFLD compared to healthy individuals and its association with some risk factors for the first time. Method This case-control study measured serum levels of Read More