The Potential of Melatonin to Treat Atherosclerosis by Targeting Mitochondria

As a circadian rhythm hormone, melatonin is widely present in the body and has rich physiological functions. Compared to its prominent circadian role, melatonin has been extensively studied in many fields as an ancient antioxidant. In addition to being considered a potent antioxidant, melatonin has also been found to play an important role in mitochondrial homeostasis. Mitochondrial oxidative stress plays a crucial role in the occurrence and development of atherosclerosis. Therefore, the possible therapeutic value of melatonin as an antioxidant targeting mitochondria in atherosclerosis is worth exploring. The most widespread clinical applications of melatonin are in circadian rhythms and sleep, but the cardiovascular system may be the most promising area.