Naturally Derived Glycosides with Potential Activity against Staphylococcus Aureus

Staphylococcus aureus (S. aureus) is one of the most common pathogens and implicated in a wide range of infections. It is responsible for a high rate of morbidity and mortality and has already posed a great burden on the healthcare system. S. aureus strains have already generated resistance to almost all available antibiotics, due to which the World Health Organization stratified S. aureus as a high tier priority II pathogen. Glycosides, the secondary metabolites of many plants in nature, possess a variety of pharmacological properties, including antibacterial activity against S. aureus. The structural and mechanistic diversity make glycosides useful weapons against S. aureus. This review summarizes the recent studies on naturally-derived glycosides and provides a comprehensive summary regarding the status of the resources and the anti-S. aureus potential.